Multidrug resistance strength of the novel multidrug resistance gene HA117: compared with MRP1.

Medical Oncology
Lihua ZhaoSiqi Wang

Abstract

The novel gene HA117 is a multidrug resistance (MDR) gene in all-trans retinoic acid resistance HL-60 cells. The transduction of adenovirus vectors encoding HA117 conferred breast cancer cell line 4T1 MDR not only to MRP1 substrate drugs but also to MRP1 non-substrate drugs and the MDR strength of HA117 was similar to that of multidrug resistance-associated protein-1 (MRP1) for MRP1 substrate, but HA117 had no daunorubicin-excretion function.

References

Nov 11, 1976·Biochimica Et Biophysica Acta·R L Juliano, V Ling
May 26, 1991·The New England Journal of Medicine·R P WarrellA Jakubowski
Jan 1, 1996·Stem Cells·R L FineC W Sachs
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·L A DoyleD D Ross
Dec 3, 1999·Biochimica Et Biophysica Acta·I KleinA Váradi
Jun 26, 2001·Research in Microbiology·C F Higgins
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Zhi-Xiang ShenZhu Chen
Mar 7, 2007·Haematologica·Francesco Lo CocoMiguel A Sanz
Jun 23, 2007·Current Gene Therapy·Samuel K Campos, Michael A Barry
Mar 4, 2008·Biological & Pharmaceutical Bulletin·Naoki TomiyamaKenji Matsuyama
Jan 13, 2009·Leukemia Research·Gai-Huan ZhengJian-Feng Zhou
May 16, 2009·Current Cancer Drug Targets·Katalin GodaGábor Szabó

❮ Previous
Next ❯

Citations

Nov 14, 2013·PloS One·Vasilij KoshkinSergey N Krylov
Dec 11, 2013·Journal of Computer-aided Molecular Design·Wen TanLi Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.