Multidrug-resistant bacterial infections in cirrhotic patients: an epidemiological study

Expert Review of Gastroenterology & Hepatology
Ruihong ZhaoJifang Sheng

Abstract

The purpose of this study is to describe the epidemiological features of bacterial infections caused by multidrug-resistant (MDR) bacteria in cirrhotic patients and their impact on mortality. A retrospective study of cirrhotic patients with culture-confirmed bacterial infections was performed between 2011 and 2017. A total of 635 episodes in 563 patients with cirrhosis were included. Bacterial infections caused by MDR isolates accounted for 44.1% (280/635) of the episodes, nearly half of which were hospital acquired (48.4%). The most common MDR isolation site was the respiratory tract (36.4%, 102 episodes), followed by the abdominal cavity (35.4%, 99 episodes). Of the MDR isolates, carbapenem-resistant Enterobacteriaceae (CRE) (91 episodes) were the most common. Patients infected with MDR bacteria had significantly higher mortality than those not infected (25.1% vs 17.4%, p = 0.025). However, this increased mortality could be largely attributed to methicillin-resistant Staphylococcus aureus (MRSA). After adjustment for age, sex, and the model for end-stage liver disease (MELD) score, only MRSA infection was an independent risk factor for 28-day mortality in the multivariable Cox proportional hazard regression model analysis (HR...Continue Reading

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Citations

Oct 22, 2019·Clinical Liver Disease·Salvatore Piano, Paolo Angeli
May 31, 2021·Gastroenterología y hepatología·Luísa Martins FigueiredoAlexandra Martins

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