Multidrug-resistant Candida auris: an epidemiological review.

Expert Review of Anti-infective Therapy
Arunaloke Chakrabarti, Shreya Singh

Abstract

Introduction: Since the emergence of Candida auris infection in 2009, the disease has been reported from multiple countries within a decade. The infection is classified under urgent threat, as it is multi-drug resistant, causes high mortality, spreads easily in hospital setting and is difficult to identify. Whole-genome sequencing has provided insights into this organisms biology and epidemiology. A comprehensive review of those issues would help the clinicians and scientists facing C. auris infection.Areas covered: We reviewed the epidemiological trends of C. auris infection, including the genomic epidemiology based on an electronic search using Pubmed and Google scholar. We also discuss the biology, virulence attributes of this pathogen, its clinical presentations and associated risk factors. The mechanisms of antifungal resistance known so far are also described in addition to factors involved in the nosocomial transmission, environmental survival and ecology of C. auris.Expert opinion: Despite the attention of multiple researchers evaluating every aspect of this organism and its epidemiology, there are several gaps in tracing its origin and understanding the dynamics of nosocomial transmission and global spread. Multidiscip...Continue Reading

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Citations

Jul 8, 2020·Journal of Fungi·Arunaloke ChakrabartiOliver A Cornely
Aug 28, 2020·Frontiers in Cellular and Infection Microbiology·Rodnei Dennis RossoniEleftherios Mylonakis
Nov 25, 2020·Chemistry : a European Journal·Angelo FreiMark A T Blaskovich
May 5, 2021·Mycoses·Harsimran KaurArunaloke Chakrabarti
May 20, 2021·Mycoses·João Nobrega de AlmeidaUNKNOWN Candida auris Brazilian Study Group
Sep 21, 2021·Frontiers in Cellular and Infection Microbiology·Priyanka S Bapat, Clarissa J Nobile
Nov 4, 2021·Mycoses·Patricia EscandónCarolina Duarte

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