Multidrug-resistant Citrobacter freundii ST139 co-producing NDM-1 and CMY-152 from China

Scientific Reports
Lang YangHongbin Song

Abstract

The emergence of carbapenemase-producing Citrobacter freundii poses a significant threat to public health worldwide. Here, we reported a C. freundii strain CWH001 which was resistant to all tested antimicrobials except tetracycline. Whole genome sequencing and analysis were performed. The strain, which belonged to a new sequence type ST139, showed close relationship with other foreign C. freundii strains through phylogenetic analysis. A novel variant of the intrinsic blaCMY gene located on the chromosome was identified and designated as blaCMY-152. Coexistence of blaNDM-1 with qnrS1 was found on a conjugative IncN plasmid, which had a backbone appearing in various plasmids. Other class A ESBL genes (blaVEB-3 and blaTEM-1) were also detected on two different novel plasmids. The emergence of multidrug-resistant C. freundii is of major concern, causing great challenges to the treatment of clinical infections. Great efforts need to be taken for the specific surveillance of this opportunistic pathogen.

References

Jan 1, 1991·Pediatric Neurosurgery·A JoaquinN al Fayez
Feb 1, 1994·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·T FujiiM Kaku
Jul 1, 1996·Applied and Environmental Microbiology·A GötzK Smalla
Oct 26, 1999·The Pediatric Infectious Disease Journal·M A Gill, G E Schutze
Sep 18, 2002·Antimicrobial Agents and Chemotherapy·Laura BriñasCarmen Torres
Mar 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gerald P Bodey
Aug 31, 2006·Antimicrobial Agents and Chemotherapy·Fernando PasteránViviana Cagnoni
Dec 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James H Jorgensen, Janet F Hindler
Feb 12, 2008·BMC Genomics·Ramy K AzizOlga Zagnitko
Feb 26, 2008·Applied and Environmental Microbiology·Jeremy A FrankGary J Olsen
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Jan 19, 2010·Bioinformatics·Heng Li, Richard Durbin
Dec 15, 2010·Bioinformatics·Marten BoetzerWalter Pirovano
Jan 13, 2012·Journal of Clinical Microbiology·Mette V LarsenOle Lund
Jun 27, 2012·Genome Biology·Marten Boetzer, Walter Pirovano
Jan 5, 2013·The Journal of Antimicrobial Chemotherapy·Zhiyong Zong, Xingzhuo Zhang
Dec 7, 2013·Expert Review of Anti-infective Therapy·Alexander M Wailan, David L Paterson
Dec 11, 2013·Antimicrobial Agents and Chemotherapy·Jia Chang CaiGong-Xiang Chen
Apr 30, 2014·Antimicrobial Agents and Chemotherapy·Alessandra CarattoliHenrik Hasman
May 24, 2014·Diagnostic Microbiology and Infectious Disease·Joseph E RubinJohann D D Pitout
Jul 1, 2015·The Journal of Antimicrobial Chemotherapy·Carl-Fredrik FlachD G Joakim Larsson
Sep 24, 2015·Antimicrobial Agents and Chemotherapy·Juliana Coutinho CamposJorge Luiz Mello Sampaio
May 18, 2016·Genome Biology and Evolution·Tereza KubasovaHelena Juricova

❮ Previous
Next ❯

Citations

Sep 14, 2021·Frontiers in Cellular and Infection Microbiology·Liyun LiuRuiting Lan

❮ Previous
Next ❯

Datasets Mentioned

BETA
CP016762
PEHH00000000

Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

SSPACE
BLAST
SOAPdenovo
JSpeciesWS
GapFiller
RAxML
MLST
PlasmidFinder

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.