Multidrug resistant Mycobacterium tuberculosis amongst Category I & II failures and Category II relapse patients from Pakistan

International Journal of Mycobacteriology
Abdul GhafoorRumina Hasan

Abstract

To determine the prevalence of multidrug-resistant tuberculosis (MDR-TB) among previously treated TB patients in Khyber Pakhtunkhwa (KP) Province, Pakistan. A cross-sectional study was conducted (January-September 2009) in 10 districts of KP. All Category (CAT) I and CAT II failures, and CAT II relapse cases were recruited within 1week following declaration of treatment outcome or re-registration of CAT II. Clinical information and sputum was collected from each patient. Total 139 patients were enrolled. Mycobacterium tuberculosis bacilli (MTB) was isolated in 113 (81.3%) samples; Mycobacterium other than tuberculosis (MOTT) was isolated in 7 (5%) samples. MDR-TB was noted in 66 (58.4%) patients and extensive drug resistant (XDR-TB) in 2 (1.8%) patients. Amongst MDR patients, 20 (62.5%) were CAT I failure, 19 (76%) CAT II failure and 27 (48.2%) CAT II relapse cases. Resistance to Isoniazid was most common in 84 (74%) cases, followed by Pyrazinamide in 73 (64.6%) cases, Rifampicin in 67 (59%) cases, Streptomycin in 60 (53%) cases, Ethambutol in 58 (51%) cases, and Ofloxacin in 18 (22.2%) cases. High rate of drug resistance, including MDR observed among failures and relapse cases. This study emphasizes the need to review TB care ...Continue Reading

References

Apr 4, 2002·The Journal of Infectious Diseases·Christopher DyeBrian G Williams
Oct 6, 2005·The Journal of Antimicrobial Chemotherapy·Tsi-Shu HuangYung-Ching Liu
Sep 19, 2006·Lancet
Dec 19, 2006·Lancet·Mohamed Abdel AzizUNKNOWN WHO/International Union Against Tuberculosis And Lung Disease Global Project on Anti-tuberculosis Drug Resistance Surveillan
Apr 17, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Rumina HasanMuhammad Masood Kadir
Apr 30, 2010·Transactions of the Royal Society of Tropical Medicine and Hygiene·Muslima EjazRumina Hasan
Aug 26, 2010·Emerging Infectious Diseases·Rumina HasanZahra Hasan

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Citations

Dec 16, 2016·Drug Development and Industrial Pharmacy·Stefano GiovagnoliMaurizio Ricci
Dec 4, 2019·International Journal of Mycobacteriology·Bilal Ahmad RahimiAbdul Wahed Wasiq

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