Multidrug-resistant organisms in neonatal sepsis in two tertiary neonatal ICUs, Egypt

The Journal of the Egyptian Public Health Association
Hesham A AwadAl-Sayed A Abd-Elrhman

Abstract

Neonatal sepsis remains a serious problem in any neonatal intensive care unit (NICU). Bacterial organisms have developed increased resistance to commonly used antibiotics. Because not enough data are available from Egypt, the aim of the present study was to determine the causative bacteria and the level of their resistance to commonly used antibiotics in tertiary NICUs in Cairo, Egypt. A 3.5-year retrospective study was carried out at NICUs of the Children's Hospital of Ain Shams University and that of El-Hussein Hospital, Al-Azhar University, Egypt. Records of neonates were reviewed. All neonates with culture-proven sepsis were included in the study. Almost one-third of the admitted neonates (33.4%) were diagnosed as having neonatal sepsis, 32.25% of them culture-proven. Early/late onset sepsis was found in 35.4 and 64.6%, respectively. Gram-negative/gram-positive bacteria was found in 68 to 25.6%. Fungal infection was detected in 9% of the isolates. Escherichia coli was the main pathogen isolated in both early-onset sepsis (41.2%) and late-onset sepsis (24.5%). Overall, 77% of the isolates were multidrug-resistant (60% of gram-positive bacteria and 83.4% of gram-negative bacteria). Nearly 80% (79%) of mortality was caused by ...Continue Reading

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Citations

Jan 24, 2020·Archives of Disease in Childhood·Nadim KhalilTyler Hartman
Jun 21, 2017·Antimicrobial Resistance and Infection Control·Lamiaa MohsenHany Aly
May 1, 2021·Tropical Medicine and Infectious Disease·Bijendra Raj RaghubanshiBal Man Singh Karki
Jun 4, 2021·Infection and Drug Resistance·Amani El-KholyRamy Kotb

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