Multidrug-resistant typhoid fever with neurologic findings on the Malawi-Mozambique border

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Emily LutterlohE D Mintz

Abstract

Salmonella enterica serovar Typhi causes an estimated 22 million cases of typhoid fever and 216 000 deaths annually worldwide. We investigated an outbreak of unexplained febrile illnesses with neurologic findings, determined to be typhoid fever, along the Malawi-Mozambique border. The investigation included active surveillance, interviews, examinations of ill and convalescent persons, medical chart reviews, and laboratory testing. Classification as a suspected case required fever and ≥1 other finding (eg, headache or abdominal pain); a probable case required fever and a positive rapid immunoglobulin M antibody test for typhoid (TUBEX TF); a confirmed case required isolation of Salmonella Typhi from blood or stool. Isolates underwent antimicrobial susceptibility testing and subtyping by pulsed-field gel electrophoresis (PFGE). We identified 303 cases from 18 villages with onset during March-November 2009; 214 were suspected, 43 were probable, and 46 were confirmed cases. Forty patients presented with focal neurologic abnormalities, including a constellation of upper motor neuron signs (n = 19), ataxia (n = 22), and parkinsonism (n = 8). Eleven patients died. All 42 isolates tested were resistant to ampicillin, chloramphenicol, a...Continue Reading

References

Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·I M SawhneyJ S Chopra
Jul 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·R S WadiaH V Sardesai
Jul 1, 1972·Archives of Neurology·B O OsuntokunS G Wright
Apr 27, 2000·The Pediatric Infectious Disease Journal·A L WalshM E Molyneux
May 5, 2001·Epidemiology·M A HernánA Ascherio
Oct 26, 2002·FEMS Microbiology Letters·Felix Mills-RobertsonScott S Crupper
Nov 1, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Momtaz O WasfyFrank J Mahoney
Nov 29, 2002·The New England Journal of Medicine·Christopher M ParryJeremy J Farrar
Apr 9, 2004·Journal of Clinical Microbiology·Samuel KariukiC Anthony Hart
Feb 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael D LewisSarala Malla
Feb 13, 2007·Travel Medicine and Infectious Disease·Fiona J Cooke, John Wain
Jan 24, 2008·Antimicrobial Agents and Chemotherapy·John A CrumpUNKNOWN Emerging Infections Program FoodNet and NARMS Working Groups
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Melita A GordonMalcolm E Molyneux
Jul 23, 2008·Journal of Child Neurology·Rajoo ThapaTrilochan S Jain
Aug 30, 2008·Current Opinion in Infectious Diseases·Christopher M Parry, E J Threlfall
Jan 10, 2009·The Pediatric Infectious Disease Journal·Betuel SigaúquePedro L Alonso
Jan 29, 2009·Travel Medicine and Infectious Disease·J J Muyembe-TamfumM Boelaert
Feb 24, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Anthony W SolomonGeoffrey Pasvol
Sep 15, 2009·Travel Medicine and Infectious Disease·Marlies E van WolfswinkelPerry J J van Genderen
Dec 22, 2009·BMC Public Health·Amber FarooquiShahana U Kazmi
Jul 3, 2010·The American Journal of Tropical Medicine and Hygiene·Inácio MandomandoPedro L Alonso
Aug 26, 2010·Emerging Infectious Diseases·Nicholas A FeaseyKaren H Keddy

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Citations

Jan 22, 2013·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Neha GargPraveen Rishi
May 9, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cedric P YansouniJan Jacobs
Aug 27, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M-F PhobaJ Jacobs
Feb 13, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Claire S WaddingtonAndrew J Pollard
Feb 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John A Crump
Feb 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Karen P NeilEric Mintz
Sep 11, 2014·Annual Review of Microbiology·Gordon Dougan, Stephen Baker
Oct 11, 2014·Transactions of the Royal Society of Tropical Medicine and Hygiene·John A Crump, Robert S Heyderman
Mar 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vera von KalckreuthFlorian Marks
Oct 10, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Virginia E PitzerRobert S Heyderman
Oct 10, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Esther MuthumbiJ Anthony G Scott
Apr 29, 2015·Vaccine·Samuel KariukiChristopher M Parry
Apr 9, 2013·Human Vaccines & Immunotherapeutics·Rachel B SlaytonEric D Mintz
Dec 3, 2014·Lancet·John WainR Leon Ochiai
Feb 19, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F ChappuisC P Yansouni
Apr 20, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kashmira A DateBarbara E Mahon
Apr 25, 2015·PLoS Neglected Tropical Diseases·Nicholas A FeaseyRobert S Heyderman
Aug 27, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S I SmithA Ajayi
Oct 26, 2016·PloS One·Karen H KeddyUNKNOWN GERMS-SA
Mar 26, 2014·The American Journal of Tropical Medicine and Hygiene·Maho ImanishiUNKNOWN Zimbabwe Typhoid Fever Outbreak Working Group 2011–2012
Jul 9, 2014·The American Journal of Tropical Medicine and Hygiene·Lauren S BlumEric D Mintz
May 11, 2016·The American Journal of Tropical Medicine and Hygiene·Takashi MatonoNorio Ohmagari
Nov 21, 2017·Emerging Infectious Diseases·Jenny A WalldorfTerri B Hyde
May 26, 2017·The Cochrane Database of Systematic Reviews·Lalith WijedoruChristopher M Parry
Jul 5, 2018·Expert Review of Vaccines·James E MeiringMelita A Gordon
Jul 27, 2018·The American Journal of Tropical Medicine and Hygiene·Karen H KeddyFrew G Benson
Mar 8, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Omari A MsemoJohn P A Lusingu
Apr 18, 2013·Current Opinion in Infectious Diseases·Alastair C McGregorAndrew J Pollard
Dec 7, 2013·Current Opinion in Gastroenterology·Thomas C DartonAndrew J Pollard
Oct 16, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Virginia E PitzerStephen Baker
Mar 11, 2020·PLoS Neglected Tropical Diseases·Paula Diaz-GuevaraStephen Baker
Apr 3, 2020·Expert Review of Vaccines·Peter J O'ReillyAndrew J Pollard
Apr 2, 2020·The American Journal of Tropical Medicine and Hygiene·Grace D AppiahEric D Mintz
Jul 25, 2012·Current Opinion in Infectious Diseases·Laura B Martin
Oct 31, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jong-Hoon KimFlorian Marks

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