Multidrug-Resistant Vibrio cholerae O1 was Responsible for a Cholera Outbreak in 2013 in Bagalkot, North Karnataka

Japanese Journal of Infectious Diseases
Debdutta BhattacharyaBasappa G Mantur

Abstract

Cholera is a major cause of illness in the developing world. During the monsoon season, small sporadic clusters of cholera cases are reported on an annual basis in Karnataka, India. During the monsoons of 2013, there was a cholera outbreak in Badami, a remote area of Bagalkot district in Karnataka. The multi-drug-resistant Vibrio cholerae O1 serotype Ogawa was found to be responsible for this outbreak. On 5 August 2013, a 30-year-old woman presented with severe dehydration and watery diarrhea at the Aganwadi Health Centre in Badami. A total of 49 suspected cholera cases were reported, with an attack rate of 3.5%. The V. cholerae isolates exhibited resistance to a wide range of drugs, including ampicillin, co-trimoxazole, nitrofurantoin, carbenicillin, and third generation cephalosporins, and showed reduced susceptibility to third generation fluoroquinolones. All of the cephalosporin-resistant V. cholerae strains produced extended-spectrum beta-lactamase. All V. cholerae O1 isolates harbored virulent genes (ctxA, ctxB, tcpA El Tor, Tox S, VPI, ToxT, ToxR, ToxRS, ace, zot, and tcpP) and were found to be genetically similar as determined by randomly amplified polymorphic DNA fingerprinting assay. To the best of our knowledge, this...Continue Reading

References

Apr 30, 2010·Bulletin of the World Health Organization·S KanungoG Balakrish Nair
Sep 16, 2011·Journal of Infection in Developing Countries·Debdutta BhattacharyaSubarna Roy
Apr 25, 2012·Journal of Health, Population, and Nutrition·Jharna MandalSubhash Chandra Parija
Jun 6, 2012·The American Journal of Tropical Medicine and Hygiene·Debdutta BhattacharyaA P Sugunan
Aug 31, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D BhattacharyaS Roy
May 27, 2014·Japanese Journal of Infectious Diseases·Hemanta KoleySubrata Ghosh

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Citations

Nov 3, 2016·Frontiers in Public Health·Daniela CeccarelliRita R Colwell
Jun 24, 2018·Frontiers of Medicine·Ali A Rabaan

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