PMID: 2484225Oct 1, 1989Paper

Multielement analysis of biological samples by inductively coupled plasma-mass spectrometry. I. Preliminary considerations and analysis of rat liver and serum

Biological Trace Element Research
D M TempletonA D Baines

Abstract

Interest in the biological behavior of a growing number of elements, along with increasing recognition of the importance of interactions among them, demands a versatile and reliable technique for multielement analysis of biological samples. Significant improvements over the sensitivity achieved with conventional inductively coupled plasma (ICP) optical emission spectrometries have been realized with the introduction of quadrupole mass spectrometry (MS) for detection of ions in the plasma. The hybrid technique of ICP-MS promises to be a method of rapid multielement analysis, at detection limits that approach or surpass those of other technologies. However, the application of ICP-MS to analyses of biological interest is truly in its infancy. Here we report the use of ICP-MS for the determination of more than 30 elements of biological interest in a tissue and a biological fluid (rat liver and serum, respectively). Experimental values of the elements serve as a basis for discussion of analytical protocols, performance criteria, and certain problems peculiar to ICP-MS.

References

Mar 1, 1986·American Journal of Hematology·M JanghorbaniS J Fomon
Oct 1, 1986·Biological Trace Element Research·G LeblondelP Allain
Apr 1, 1987·Biological Trace Element Research·J VersieckD Van Renterghem
Aug 1, 1987·Biological Trace Element Research·M A Chaudhri, P Hannaker

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Citations

Aug 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·B OrserA Gelb
Jun 6, 1994·The Science of the Total Environment·D M TempletonL Stuhne-Sekalec
Apr 17, 1990·Toxicology·D M Templeton, N Chaitu
Aug 5, 1999·Toxicology·C H LinS S Chen
Dec 28, 1999·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·M Krachler, K J Irgolic
Nov 20, 2002·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Wojciech M KwiatekTadeusz Cichocki
Jun 1, 1990·Analytical Chemistry·D W Koppenaal

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