Multifaceted regulation and functions of YAP/TAZ in tumors (Review).

Oncology Reports
Huirong LiuYi Wang

Abstract

The Hippo pathway, initially identified through screenings for mutant tumor suppressors in Drosophila, is an evolutionarily conserved signaling pathway that controls organ size by regulating cell proliferation and apoptosis. Abnormal regulation of the Hippo pathway may lead to cancer in mammals. As the major downstream effectors of the Hippo pathway, unphosphorylated Yes-associated protein (YAP) and its homolog transcriptional co-activator TAZ (also called WWTR1) (hereafter called YAP/TAZ) are translocated into the nucleus. In the nucleus, in order to induce target gene expression, YAP/TAZ bind to the TEA domain (TEAD) proteins, and this binding subsequently promotes cell proliferation and inhibits apoptosis. In contrast, as key regulators of tumorigenesis and development, YAP/TAZ are phosphorylated and regulated by multiple molecules and pathways including Lats1/2 of Hippo, Wnt and G-protein-coupled receptor (GPCR) signaling, with a regulatory role in cell physiology, tumor cell development and pathological abnormalities simultaneously. In particular, the crucial role of YAP/TAZ in tumors ensures their potential as targets in designing anticancer drugs. To date, mounting research has elucidated the suppression of YAP/TAZ via e...Continue Reading

Citations

Aug 22, 2020·Cancer Management and Research·Xiaolan WenWen Zhang
Apr 2, 2019·Frontiers in Cell and Developmental Biology·Saumya Manmadhan, Ursula Ehmer
Apr 8, 2020·Cells·Hyunwoo KimBuHyun Youn
Oct 25, 2020·Journal of Cancer Research and Clinical Oncology·Richard DrexlerKarl J Oldhafer
Nov 22, 2020·Journal of Experimental & Clinical Cancer Research : CR·Zhenqiang SunQuancheng Kan
Oct 18, 2020·International Journal of Molecular Sciences·Anita K Luu, Alicia M Viloria-Petit
May 29, 2021·OncoTargets and Therapy·Lingling YeQuan An Zhang
Jun 3, 2021·International Journal of Molecular Sciences·Bo YuBernard A J Roelen

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation
GTPases
GTPase
oncotherapy
acetylation

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.