Multifaceted regulation of hepatic lipid metabolism by YY1.

Life Science Alliance
Gang PanClaes Wadelius

Abstract

Recent studies suggested that dysregulated YY1 plays a pivotal role in many liver diseases. To obtain a detailed view of genes and pathways regulated by YY1 in the liver, we carried out RNA sequencing in HepG2 cells after YY1 knockdown. A rigid set of 2,081 differentially expressed genes was identified by comparing the YY1-knockdown samples (n = 8) with the control samples (n = 14). YY1 knockdown significantly decreased the expression of several key transcription factors and their coactivators in lipid metabolism. This is illustrated by YY1 regulating PPARA expression through binding to its promoter and enhancer regions. Our study further suggest that down-regulation of the key transcription factors together with YY1 knockdown significantly decreased the cooperation between YY1 and these transcription factors at various regulatory regions, which are important in regulating the expression of genes in hepatic lipid metabolism. This was supported by the finding that the expression of SCD and ELOVL6, encoding key enzymes in lipogenesis, were regulated by the cooperation between YY1 and PPARA/RXRA complex over their promoters.

Associated Datasets

References

Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·C W Miller, J M Ntambi
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Mar 12, 2010·Critical Reviews in Biochemistry and Molecular Biology·Maggie S Strable, James M Ntambi
Aug 3, 2010·Trends in Endocrinology and Metabolism : TEM·Philippe LefebvreBart Staels
Sep 18, 2010·PPAR Research·Lena BurriRolf K Berge
Oct 12, 2010·PPAR Research·Maryam RakhshandehrooSander Kersten
Dec 1, 2010·Nucleic Acids Research·Donna MaglottTatiana Tatusova
Mar 30, 2012·Omics : a Journal of Integrative Biology·Guangchuang YuQing-Yu He
May 10, 2012·PLoS Genetics·Juying LiDavid E Fisher
Jul 4, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Takashi MatsuzakaHitoshi Shimano
Sep 8, 2012·Nature·UNKNOWN ENCODE Project Consortium
Feb 12, 2013·Journal of Gastroenterology·Yuki Kawano, David E Cohen
Mar 19, 2013·Cell·Matthias Merkenschlager, Duncan T Odom
Nov 14, 2013·Seminars in Liver Disease·Xu XuAnn-Hwee Lee
Jan 29, 2014·Molecular Endocrinology·Francisco VerdeguerPere Puigserver
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders
Mar 31, 2015·Current Cancer Drug Targets·Jinming ShiGuangchao Sui
Oct 8, 2015·Journal of Lipid Research·GuQi WangFrank J Burczynski
Oct 23, 2015·Nature Reviews. Molecular Cell Biology·Yuhui WangHei Sook Sul
Apr 16, 2016·Nucleic Acids Research·Fidel RamírezThomas Manke
May 5, 2016·Nucleic Acids Research·Maxim V KuleshovAvi Ma'ayan
Nov 2, 2016·Nucleic Acids Research·Klev DiamantiJan Komorowski
Dec 10, 2016·Nucleic Acids Research·Gang PanClaes Wadelius
Apr 4, 2017·The Journal of Clinical Investigation·Vanessa DuboisBart Staels
Nov 28, 2017·Journal of Hepatology·Hwee Hui LauAdrian Kee Keong Teo
Dec 12, 2017·Cell·Abraham S WeintraubRichard A Young
Dec 23, 2017·Seminars in Liver Disease·Mengjie ZhangBing Ni
Apr 22, 2018·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Chi-Yu LaiGuor Mour Her
Jul 4, 2018·Nature Medicine·Scott L FriedmanArun J Sanyal
Sep 5, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair YounossiMiriam B Vos
Sep 30, 2018·Journal of Hepatology·Sumeet K AsraniPatrick S Kamath

❮ Previous
Next ❯

Citations

Jun 26, 2021·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Gang PanClaes Wadelius

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Critical Reviews in Oncogenesis
Qiang ZhangGuangchao Sui
Proceedings of the National Academy of Sciences of the United States of America
Eden KleimanAnn J Feeney
Critical Reviews in Oncogenesis
Raed Rizkallah, Myra M Hurt
© 2021 Meta ULC. All rights reserved