Multifaceted Roles of Beige Fat in Energy Homeostasis Beyond UCP1

Endocrinology
Carlos Henrique Sponton, Shingo Kajimura

Abstract

Beige adipocytes are an inducible form of thermogenic adipose cells that emerge within the white adipose tissue in response to a variety of environmental stimuli, such as chronic cold acclimation. Similar to brown adipocytes that reside in brown adipose tissue depots, beige adipocytes are also thermogenic; however, beige adipocytes possess unique, distinguishing characteristics in their developmental regulation and biological function. This review highlights recent advances in our understanding of beige adipocytes, focusing on the diverse roles of beige fat in the regulation of energy homeostasis that are independent of the canonical thermogenic pathway via uncoupling protein 1.

References

Aug 21, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·V GolozoubovaJ Nedergaard
Oct 3, 2002·Nature Medicine·Hong-Ping GuanMitchell A Lazar
Jun 6, 2003·The Journal of Biological Chemistry·Lea ReshefRichard W Hanson
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
Aug 18, 2006·The Journal of Biological Chemistry·Jozef UkropecLeslie P Kozak
Oct 26, 2006·Journal of Cellular Physiology·Julie S MoyersAlexei Kharitonenkov
Oct 24, 2008·Molecular Endocrinology·Mayoura KeophiphathDanièle Lacasa
Dec 31, 2008·Molecular and Cellular Biology·Tayeba KhanPhilipp E Scherer
Feb 15, 2011·The Journal of Biological Chemistry·Elayne HondaresFrancesc Villarroya
Feb 4, 2012·Genes & Development·Ffolliott M FisherBruce M Spiegelman
Jul 10, 2012·Nature Medicine·Thomas A Wynn, Thirumalai R Ramalingam
Sep 11, 2012·Nature Medicine·Naresh C BalMuthu Periasamy
Nov 21, 2012·PloS One·Louis Z SharpShingo Kajimura
Dec 12, 2012·The Journal of Clinical Investigation·Kristin I StanfordLaurie J Goodyear
Feb 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Shu-Wen QianQi-Qun Tang
Apr 23, 2013·Nature Medicine·Martin E LidellSven Enerbäck
Jul 23, 2013·The Journal of Clinical Investigation·Takeshi YoneshiroMasayuki Saito
Jul 23, 2013·The Journal of Clinical Investigation·Anouk A J J van der LansWouter D van Marken Lichtenbelt
Aug 21, 2013·Cell Metabolism·Kai SunPhilipp E Scherer
Dec 5, 2013·American Journal of Physiology. Endocrinology and Metabolism·Denise E LackeySean H Adams
Jan 21, 2014·Cell·Evan D Rosen, Bruce M Spiegelman
Feb 20, 2014·American Journal of Physiology. Endocrinology and Metabolism·Meritxell RosellMark Christian
Jun 20, 2014·Molecular Metabolism·Kai SunPhilipp E Scherer
Aug 27, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mariëtte R BoonPatrick C N Rensen
Jan 13, 2015·Nature Communications·Shannon M ReillyAlan R Saltiel
Mar 17, 2015·Nature Medicine·Kosaku ShinodaShingo Kajimura
May 9, 2015·Cell Metabolism·Murielle M VéniantDavid J Lloyd
May 10, 2015·Cell Reports·Ricardo J SammsAndrew C Adams
May 29, 2015·Genes & Development·Tomoaki IwayamaLorin E Olson

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Citations

Jan 29, 2019·Adipocyte·Xiaodan Lu
Mar 23, 2019·Endocrine Reviews·Julian M YabutGregory R Steinberg
Jun 17, 2020·The Biochemical Journal·Alice E Pollard, David Carling
Jan 12, 2019·Frontiers in Physiology·Lise MadsenKarsten Kristiansen
Apr 25, 2021·Biochemical and Biophysical Research Communications·Guoying ZhangLei Cui
Jan 15, 2021·Endocrine Journal·Tuohua MaoChuanhai Zhang
Jun 3, 2021·International Journal of Molecular Sciences·Bruna B BrandãoAtefeh Rabiee

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