PMID: 15387978Sep 25, 2004Paper

Multifactor analysis of relationship between the biological exposure to iodine and hypothyroidism

Zhonghua yi xue za zhi
Wei ChongYa-jie Tong

Abstract

To assess the relationship between the biological exposure to iodine and hypothyroidism. Logistic regression model was used to analyze the risk factors of hypothyroidism, according to the epidemiologic data of 3761 adults in 3 kinds of rural communities: mild iodine deficiency area (4 natural villages in Panshan County, Liaoning Province), more than adequate iodine (7 natural villages of Zhangwu County, Liaoning Province), and excessive iodine area (2 natural villages of Huanghua City, Hebei Province). More than adequate iodine and excessive iodine were independent risk factors of subclinical hypothyroidism (OR = 3.172 and 6.391, P < 0.05) and overt hypothyroidism (OR = 3.696 and 9.213, P < 0.05). When interactions of iodine exposure and thyroid peroxidase antibody (TPOAb) or thyroglobulin antibody (TgAb) were included, more than adequate iodine was still a risk factor of subclinical hypothyroidism (OR = 2.788, P < 0.01), but had no such effect on overt hypothyroidism. Interaction of more than adequate iodine and positive TgAb significantly affected subclinical hypothyroidism and overt hypothyroidism (OR = 2.656 and 3.347, P < 0.05). More than adequate and excessive iodine exposure are independent risk factors of hypothyroidism...Continue Reading

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Zeitschrift für ärztliche Fortbildung
J Adam, H Enke
Acta otorrinolaringológica española
G Dañino GonzálezJ C García Rodríguez
Zhonghua wai ke za zhi [Chinese journal of surgery]
C Zhu
© 2021 Meta ULC. All rights reserved