Multifactorial Analysis of Prognostic Factors and Survival Rates Among 706 Mucosal Melanoma Patients

Annals of Surgical Oncology
ChuanLiang CuiJ Guo

Abstract

The hypothesis that mucosal melanomas from different anatomic sites would have different prognostic features and survival outcome was tested in a multifactorial analysis. Complete clinical and pathological information from 706 mucosal melanoma patients from different anatomical sites was compared for overall survival (OS) and prognostic factors. Mucosal melanomas arising from different anatomical sites did not have any significant differences in OS in a multivariate analysis (p = 0.721). Among all 706 stage I-IV mucosal melanoma patients, depth of tumor invasion (p < 0.001), number of lymph node metastases (p < 0.001), and sites of distant metastases (p < 0.001) were independent prognostic factors for OS; among 543 stage I-III patients, depth of tumor invasion (p < 0.001) and number of lymph node metastases (p < 0.001) were independent prognostic factors for OS; and among 547 stage IV patients, depth of tumor invasion (p = 0.009), number of lymph node metastases (p < 0.001), and combined distant metastases and elevation of serum lactate dehydrogenase (LDH; p < 0.001) were independent prognostic factors for OS. The presence of c-KIT or BRAF mutations was not predictive of survival. This is the first large-scale study comparing o...Continue Reading

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Citations

Feb 23, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·E SaracC Garbe
Aug 4, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jiayi YuYan Kong
Aug 9, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Michiel C T van ZeijlJohn B A G Haanen
Jun 3, 2021·International Journal of Molecular Sciences·Natasha M van PoppelenRobert M Verdijk

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