PMID: 19916906Nov 18, 2009Paper

Multifactorial nature of high frequency of mitochondrial DNA mutations in somatic mammalian cells

Biochemistry. Biokhimii︠a︡
I N Todorov, G I Todorov

Abstract

The high frequency of mitochondrial DNA (mtDNA) mutations in somatic mammalian cells, which is more than two orders of magnitude higher than the mutation frequency of nuclear DNA (nDNA), significantly correlates with development of a variety of mitochondrial diseases (neurodegenerative diseases, cardiomyopathies, type II diabetes mellitus, cancer, etc.). A direct cause-consequence relationship has been established between mtDNA mutations and aging phenotypes in mammals. However, the unclear nature of the high frequency of mtDNA mutations requires a comprehensive consideration of factors that contribute to this phenomenon: oxidative stress, features of structural organization and repair of the mitochondrial genome, ribonucleotide reductase activity, replication errors, mutations of nuclear genes encoding mitochondrial proteins.

References

Jan 1, 1979·Annual Review of Biochemistry·L Thelander, P Reichard
Jan 1, 1990·Free Radical Biology & Medicine·B Bandy, A J Davison
Aug 1, 1988·Molecular and Cellular Biology·R P Fisher, D A Clayton
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C RichterB N Ames
Jan 1, 1985·Advances in Enzyme Regulation·J G Cory, G L Carter
Jul 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·D A ClaytonE C Friedberg
Mar 1, 1994·Trends in Genetics : TIG·R GrosschedlJ Pagel
Oct 1, 1995·Trends in Biochemical Sciences·E SeebergM Bjørås
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·F M Yakes, B Van Houten
Feb 1, 1996·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·M Sekiguchi
Jul 1, 1997·The Biochemical Journal·H E KrokanG Slupphaug
Jan 1, 1997·Annual Review of Biochemistry·G S Shadel, D A Clayton
Mar 6, 1998·Molecular and Cellular Biology·K G Pinz, D F Bogenhagen
Apr 30, 1998·Physiological Reviews·K B Beckman, B N Ames
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·S MelovD C Wallace
Jul 17, 1999·Nature·D C Krakauer, A Mira
Aug 14, 1999·European Journal of Biochemistry·O KleinerA Batschauer
Aug 24, 1999·Nucleic Acids Research·G CoffeyC Campbell
Sep 16, 1999·Mutation Research·L A Marcelino, W G Thilly
Aug 5, 2000·Science·J KaukonenA Suomalainen
May 30, 2001·Advanced Drug Delivery Reviews·T Pulkes, M G Hanna
Jun 1, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L van den Heuvel, J Smeitink
Sep 14, 2001·Progress in Nucleic Acid Research and Molecular Biology·Y Nakabeppu
Oct 2, 2001·American Journal of Medical Genetics·A Suomalainen, J Kaukonen
Oct 24, 2001·Human Molecular Genetics·E A Shoubridge
Nov 13, 2002·Mutation Research·Bhaskar S MandavilliBennett Van Houten
Mar 7, 2003·Advances in Clinical Chemistry·Yau-Huei Wei, Hsin-Chen Lee
Apr 18, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Guo-Min Li
May 6, 2003·Biochemical and Biophysical Research Communications·Anne Chomyn, Giuseppe Attardi
Jul 15, 2003·The Journal of Biological Chemistry·Daisuke YoshimuraYusaku Nakabeppu

❮ Previous
Next ❯

Citations

May 1, 1991·Biulleten' eksperimental'noĭ biologii i meditsiny·T B KrokhinaI V Gar'kavtsev
Nov 26, 2010·Molekuliarnaia biologiia·I O MazuninR I Sukernik
Aug 24, 2013·International Journal of Molecular Sciences·Sylwester GlowackiJanusz Blasiak
Dec 15, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·H De VittoJ A Radosevich
Jan 5, 2011·Biochimica Et Biophysica Acta·Anne-Laure Bulteau, Aurelien Bayot
Aug 14, 2015·BMC Cancer·Maohua XieXingming Deng
Jul 5, 2016·Oxidative Medicine and Cellular Longevity·Gabriela Vilema-EnríquezJavier Camacho
Jun 22, 2012·Integrative Psychological & Behavioral Science·Cristian Tileagă
Aug 29, 2018·Mitochondrial DNA. Part B, Resources·Lian LiYouyong Lu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.