Multifactorial pathogenesis of COVID-19-related coagulopathy. Can defibrotide have a role in the early phases of coagulation disorders?

Journal of Thrombosis and Haemostasis : JTH
Antonio MacciòGiorgio La Nasa

Abstract

Thrombotic complications emerged as an important issue in patients with coronavirus disease 2019 (COVID-19). Consolidated reports regarding the clinical and laboratory findings in COVID-19 patients reveal thrombocytopenia, elevated D-dimer, prolonged prothrombin time, disseminated intravascular coagulation, and pulmonary intravascular coagulation (PIC). Recently, some authors emphasized the potential role of antiphospholipid antibodies in the pathogenesis of thrombotic events in patients with severe COVID-19.

References

Oct 4, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Martha K Cathcart
Dec 3, 2005·Nature Reviews. Immunology·Stanley Perlman, Ajai A Dandekar
Apr 28, 2007·Circulation Research·Sean M Davidson, Michael R Duchen
Nov 26, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Ivo M B FrancischettiMichael Waisberg
Dec 6, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kasiani C MyersSonata Jodele
May 18, 2013·Vascular Pharmacology·R PescadorM E Ferrero
Nov 17, 2016·Proceedings of the National Academy of Sciences of the United States of America·Lilach Gutter-KaponIsrael Vlodavsky
Feb 20, 2020·Journal of Thrombosis and Haemostasis : JTH·Ning TangZiyong Sun
Apr 9, 2020·The New England Journal of Medicine·Yan ZhangShuyang Zhang
Apr 24, 2020·Journal of Thrombosis and Haemostasis : JTH·Inès HarzallahBernard Drénou
May 7, 2020·Journal of Thrombosis and Thrombolysis·F Burcu Belen-Apak, F Sarıalioğlu
May 8, 2020·Nature Reviews. Immunology·Miriam Merad, Jerome C Martin
May 8, 2020·Journal of Thrombosis and Haemostasis : JTH·Nathan T ConnellJean M Connors
May 8, 2020·Journal of Thrombosis and Haemostasis : JTH·Ning Tang
May 22, 2020·The New England Journal of Medicine·Maximilian AckermannDanny Jonigk

❮ Previous
Next ❯

Citations

Aug 18, 2020·Drugs·Adrija HajraWilbert S Aronow
Sep 19, 2020·Journal of Thrombosis and Haemostasis : JTH·Antonio MacciòGiorgio La Nasa
Dec 9, 2020·International Immunopharmacology·Luiz Henrique Agra Cavalcante-SilvaSandra Rodrigues-Mascarenhas
Sep 20, 2021·Journal of Thrombosis and Haemostasis : JTH·Azita H TalasazBehnood Bikdeli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Zhonghua wei zhong bing ji jiu yi xue
Shengjian ZhongWeiqin Li
Archives of Pathology & Laboratory Medicine
Yang FeiWenjing Cao
Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology
Geoffrey D Wool, Jonathan L Miller
© 2021 Meta ULC. All rights reserved