PMID: 8957200Nov 1, 1996Paper

Multifactorial treatment of hypertensive men at high cardiovascular risk and low-density lipoprotein cholesterol affinity to human arterial proteoglycans

European Journal of Clinical Investigation
Björn FagerbergR J Wikstrand

Abstract

The purpose of this work was to examine in an open, randomized parallel-group study whether an intervention programme directed towards hypercholesterolaemia, smoking and diabetes mellitus in treated hypertensive men was associated with less complex formation between low-density lipoprotein (LDL) and human arterial proteoglycans than was the case with usual care. The intervention consisted mainly of non-pharmacological treatment, but drug therapy could be instituted to achieve the treatment goals in the intervention group. The intervention programme was associated with a significant reduction in body mass index, and 46% of the patients were on lipid-lowering medication at the follow-up examination. The net differences were (intervention--usual care): change in serum LDL-cholesterol, -0.48 mmol L-1 (95% confidence interval -0.84 to -0.11 mmol L-1), precipitated LDL-cholesterol, -5.5 micrograms (95% CI -9.0 to -1.1 micrograms). The latter remained after adjustment for the difference in serum LDL-cholesterol between groups. Our conclusion is that the multifactorial risk factor treatment programme was associated with a reduced tendency of LDL to form complexes with human arterial proteoglycans.

Citations

Oct 1, 2014·PloS One·Gemma Flores-MateoUNKNOWN PREDIMED Study Investigators
Jun 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·E Hurt-CamejoG Camejo
Aug 15, 2003·The Cochrane Database of Systematic Reviews·R L ThompsonS Ebrahim

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