Multifocal electroretinographic evaluation of long-term hydroxychloroquine users

Archives of Ophthalmology
Raj K MaturiRichard G Weleber

Abstract

To observe the long-term effects of hydroxychloroquine sulfate on retinal electrical activity by multifocal electroretinography (mfERG) and to evaluate the regional variation of retinal dysfunction in subjects with hydroxychloroquine retinopathy. Multifocal ERG with 103-hexagon stimulation was performed on 19 patients (36 eyes) treated with hydroxychloroquine for systemic lupus erythematosus, rheumatoid arthritis, or localized atypical scleroderma. Visual acuity testing, Amsler grid testing, and Ishihara color vision testing were also performed. In 2 of the patients, hydroxychloroquine was discontinued due to concerns about toxicity. Both of these patients had additional mfERG performed after discontinuation of medication. Twelve patients (19 eyes) had a normal response density in one or both eyes, including 6 patients (12 eyes) with a low lifetime dose (< or =438 g) of hydroxychloroquine who had normal response densities in both eyes. Eleven patients (17 eyes) had abnormal response densities in one or both eyes, and 2 of these patients (4 eyes) had significant attenuation of response densities in almost the whole tested field; 4 patients had a normal mfERG result for one eye but had a slight decrease of response densities for ...Continue Reading

Citations

Apr 19, 2005·The British Journal of Ophthalmology·A G Lee
Jun 15, 2007·Archives of Ophthalmology·Julio A Rodriguez-PadillaJames G Fujimoto
Apr 8, 2009·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Marcella NebbiosoPanagiotis Karavitis
Jun 29, 2006·Documenta Ophthalmologica. Advances in Ophthalmology·Timothy Y Y LaiDennis S C Lam
Jun 15, 2007·Documenta Ophthalmologica. Advances in Ophthalmology·Regina Halfeld Furtado de MendonçaWalter Yukihiko Takahashi
May 10, 2008·Documenta Ophthalmologica. Advances in Ophthalmology·Jonathan S Lyons, Matthew L Severns
Feb 4, 2011·Documenta Ophthalmologica. Advances in Ophthalmology·M RasterJ Kremers
Jan 22, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Lucia TangaGianluca Manni
Jan 5, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Susann Missner, Ulrich Kellner
Mar 23, 2011·Expert Opinion on Drug Safety·Crispin AbarientosJulia Y Ash
Apr 25, 2008·Seminars in Ophthalmology·Rodney TehraniWalter M Jay
Jul 30, 2014·Cutaneous and Ocular Toxicology·Puneet AgarwalGun Suk Chyn
Apr 25, 2007·Current Eye Research·Solange Rios SalomãoMarcia Motono
Oct 16, 2015·Indian Journal of Ophthalmology·Hemang K PandyaVinay A Shah
Feb 1, 2015·Documenta Ophthalmologica. Advances in Ophthalmology·Richard BergholzDaniel J Salchow
Mar 18, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Yasha S ModiHoward F Fine
Dec 17, 2014·Documenta Ophthalmologica. Advances in Ophthalmology·Vivienne C GreensteinDonald C Hood
Oct 3, 2015·Rheumatology·Hui Jen DingCaroline Gordon
Nov 12, 2015·Case Reports in Ophthalmological Medicine·José Antonio Sáez-MorenoJosé Manuel Rodríguez-Ferrer
Mar 6, 2007·American Journal of Ophthalmology·Jonathan S Lyons, Matthew L Severns
Jan 11, 2007·Survey of Ophthalmology·Timothy Y Y LaiDennis S C Lam
Mar 3, 2018·Cutaneous and Ocular Toxicology·Mustafa ErenAli Hakan Durukan
Mar 9, 2018·Current Opinion in Rheumatology·Nada AbdulazizWilliam J McCune
Aug 31, 2017·Documenta Ophthalmologica. Advances in Ophthalmology·Hande Husniye TelekFirdevs Ornek
Nov 1, 2007·Dermatologic Therapy·Sunil Kalia, Jan P Dutz
Nov 4, 2008·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Brian Brown
Jul 1, 2010·Retinal Cases & Brief Reports·Parveen SenRupak Roy
Oct 27, 2005·Documenta Ophthalmologica. Advances in Ophthalmology·Radouil Tzekov
Jun 11, 2010·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Marcella NebbiosoEduardo Rispoli
Nov 30, 2011·International Ophthalmology Clinics·Leanne T LabriolaAmani A Fawzi
Jan 14, 2020·Documenta Ophthalmologica. Advances in Ophthalmology·Federica BertoliMarko Hawlina
Oct 12, 2019·Translational Vision Science & Technology·Husam AlghanemNaheed W Khan
Aug 29, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Giulio RubertoGiovanni Milano
Aug 18, 2020·Journal of Medical Internet Research·Matthew MichelsonSteven Minton

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.