Multifocal ERG responses in infants.

Investigative Ophthalmology & Visual Science
Ronald M HansenAnne B Fulton

Abstract

To assess function of the central retina in 10-week-old infants, multifocal electroretinograms (mfERGs) were recorded. mfERG responses represent postreceptor retinal activity. In infants (n = 23) and adults (n = 10), mfERG responses to both unscaled and scaled 61 hexagon arrays were recorded. Amplitude and implicit time of negative (N(1), N(2)) and positive (P(1)) peaks of the first-order kernel were examined. The response from the entire area stimulated and responses to concentric rings were analyzed separately. The overall averaged response of the first slice of the second-order kernel was also evaluated. Results from infants and adults were compared. Amplitudes of the infants' responses (N(1), P(1), N(2)) were significantly smaller and implicit times were significantly longer than those of adults. In infants, amplitude and implicit time varied little with eccentricity. In adults, amplitude decreased with eccentricity, whereas implicit time varied little. In infants, the second-order kernel was relatively more attenuated than the first-order kernel. The infants' mfERG responses indicated immaturities of processing in the central retina. Infant-adult differences in the distribution of cones and bipolar cells may account for th...Continue Reading

Citations

Jun 2, 2009·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Anne B FultonAnne Moskowitz
Dec 14, 2011·Journal of Visualized Experiments : JoVE·Donnell J Creel
Jan 31, 2016·Documenta Ophthalmologica. Advances in Ophthalmology·Marta MichalczukMałgorzata Krętowska
Jul 1, 2009·Progress in Retinal and Eye Research·Anne B FultonJames D Akula
Oct 20, 2015·Documenta Ophthalmologica. Advances in Ophthalmology·Anna E C MolnarGerd E Holmström
Sep 28, 2016·Progress in Retinal and Eye Research·Ronald M HansenAnne B Fulton
Oct 2, 2019·Documenta Ophthalmologica. Advances in Ophthalmology·Ana Amorim-de-SousaJosé M González-Méijome
Apr 12, 2011·Current Opinion in Ophthalmology·Dominique Brémond-GignacUNKNOWN European Network of Study and Research in Eye Development
Feb 2, 2019·Documenta Ophthalmologica. Advances in Ophthalmology·Dylan VatcherPierre Lachapelle
Jun 8, 2013·Documenta Ophthalmologica. Advances in Ophthalmology·Rain G BosworthKaren R Dobkins

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