PMID: 9524706Apr 3, 1998Paper

Multifocal extremity sarcoma: an uncommon and controversial entity

Annals of Surgical Oncology
S L BlairM F Brennan

Abstract

The primary site of metastasis from extremity sarcomas is the lung. When patients with extremity sarcoma present with the disease in more than one site but not in the lung, the question of whether the disease is multifocal or metastatic is difficult to resolve. We reviewed 1423 patients admitted with extremity sarcoma from 1982 through 1996. Patient demographics, primary site, other sites, local recurrence, distant metastasis, and survival were analyzed. Statistics were by Fischer exact test, chi 2, Kaplan-Meier method, and log-rank test where appropriate. Sixteen (1%) patients were identified with multifocal disease out of 1423 patients with extremity sarcoma. There was no difference in sex, age, size, grade, depth, and margins between multifocal and unifocal disease. In a mean follow-up time of 57 months, 50% had local recurrence of primary tumor, 80% had distant metastasis, and only 30% were alive at the time of the analysis. Whereas 21% of all patients with solitary disease develop lung metastasis, 63% of patients with apparent multifocal disease develop lung metastasis. The 5-year disease-specific survival of patients with multifocal disease was not different from that of all patients presenting with metastatic disease to ...Continue Reading

References

Feb 1, 1992·Acta Orthopaedica Scandinavica·A Alho, T Eeg Larsen
Jul 1, 1986·The Japanese Journal of Surgery·K ShibataA Sumiyoshi
Aug 1, 1983·Archives of Surgery·M P VezeridisC P Karakousis
Sep 1, 1995·The British Journal of Surgery·C P KarakousisD L Walsh
Sep 1, 1960·Cancer·H T ENTERLINEL W BRADY

❮ Previous
Next ❯

Citations

Jan 9, 2016·The American Journal of Case Reports·Ghodratollah NowrastehSadir Alrawi
Jan 26, 2007·Annals of Surgical Oncology·Joseph H SchwabCristina R Antonescu
Dec 22, 2007·Skeletal Radiology·Kenneth SheahMiriam A Bredella
Apr 7, 2010·Sarcoma·J L NobleI Judson
May 27, 2011·Annals of Surgical Oncology·Markus P GhadimiDina Lev
Dec 9, 2014·Journal of Surgical Oncology·Nader N MassarwehDaniel A Anaya
Jan 1, 2012·Revista Brasileira De Ortopedia·Jorge Sayum FilhoMoisés Cohen
Jun 26, 2021·Journal of Surgical Case Reports·Yuta UshidaYu Takahashi
Nov 6, 2004·Cancer Genetics and Cytogenetics·Avery A Sandberg
Dec 21, 2010·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Aviad HoffmanDina Lev

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal de radiologie, d'électrologie, et de médecine nucléaire
F JAUMESM PY
Duodecim; lääketieteellinen aikakauskirja
P E NYLANDER, S AUKEE
Zentralblatt für allgemeine Pathologie und pathologische Anatomie
H Kühn
© 2022 Meta ULC. All rights reserved