Multifocal muscle candidiasis of the legs in a patient with acute myeloid leukemia: A case report

Medicine
Ping YiLanjuan Li

Abstract

Opportunistic infections frequently develop in immunocompromised patients, such as those with hematological malignancies, causing significant mortality. Early diagnosis of invasive fungal infections is often important and difficult due to the difficult nature of confirming infection using cytologic and histologic findings. However, we report the first case of candidal infection leading to muscle abscesses in the legs of a patient with leukemia. A 60-year-old man with acute myeloid leukemia (AML) presented with multifocal muscle abscesses of the legs. Multifocal muscle candidiasis of the legs was confirmed by fine-needle aspiration biopsy of 2 of the calf lesions. After treatment with amphotericin B and flucytosine for 1 month, the patient was administered intravenous caspofungin for 3 months. A CT scan of the abdomen and an MRI of the lower calves showed significant improvement. This case highlights that fungal infection should be considered when patients present with multiple abscesses, emphasizing the value of early biopsy to confirm diagnosis and facilitate precision treatment.

References

Jan 1, 1988·Annals of Internal Medicine·M ThalerP A Pizzo
Nov 26, 2003·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Perla VicariMaria Stella Figueiredo
Apr 27, 2013·Ocular Immunology and Inflammation·Florence SantiaguIqbal Tajunisah
Jun 9, 2016·Virulence·Michaela SpitzerGerard D Wright
Aug 5, 2017·The Lancet Infectious Diseases·David S PerlinAna Alastruey-Izquierdo
Feb 3, 2018·Turkish Journal of Haematology : Official Journal of Turkish Society of Haematology·Maria N GamaletsouNikolaos V Sipsas

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Methods Mentioned

BETA
biopsy

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