Multifocal "tapete" papillary fibroelastoma

Journal of Clinical Pathology
K B LawJ Butany

Abstract

Papillary fibroelastomas (PFEs) are benign cardiac tumours that typically arise on diseased aortic or mitral valves. Usually solitary, PFEs are characterised by numerous frond-like branches attached to the valve surface by a single stalk, elastic tissue present within the central core, and the appearance of a sea anemone when immersed in water. PFEs have a predilection for men with a mean age of 56 years. A very rare case of a 25-year-old man with multiple lesions on the aortic and mitral valves and a large confluent "carpet-like" lesion in the left ventricular cavity is presented. Admitted with a significant left middle cerebral artery stroke and hemiplegia, investigations showed a left ventricular outflow tract lesion, with surgical excision displaying a multifocal "carpet-like" PFE. Histopathological examination showed various lesions presenting with a short stem, several fronds arising from each stem like a "tree trunk", and elastic tissue within the central core. This case is presented, along with a review of 833 reported cases of PFEs published after the year 2001. It is believed that this is the first reported instance of surgically resected and morphologically confirmed multiple PFEs seen and removed at one operation.

Citations

Oct 19, 2010·Journal of Cardiothoracic Surgery·Neerod K JhaNorbert Augustin
Aug 29, 2013·Case Reports in Medicine·Nowell M FineJoseph J Maleszewski
Apr 14, 2011·International Journal of Clinical and Experimental Pathology·Abbas Agaimy, Thomas Strecker
Jan 17, 2016·Journal of Cardiothoracic Surgery·Jun ShiYing-qiang Guo
May 7, 2014·Journal of Clinical Ultrasound : JCU·Mariana FloriaErwin Schroeder
Jul 12, 2014·Journal of Cardiothoracic Surgery·Thomas StreckerAbbas Agaimy
Jan 23, 2016·Echo Research and Practice·Jenny DukeAndrew Dettrick
May 8, 2020·Kardiologiia·F Yu ValikulovaM B Kozina
Sep 29, 2020·Clinical Case Reports·Henry O SavageJason Dungu
May 23, 2021·The Annals of Thoracic Surgery·Ahmed A SorourKyle W Klarich

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