Multifocal visual evoked potentials in optic neuritis and multiple sclerosis: A review

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Gorm Pihl-JensenJette Lautrup Frederiksen

Abstract

Multifocal visual evoked potential (mf-VEP) represents a new approach to the classical full field (ff-)VEP with separate responses from up to 60 sectors of the visual field. A thorough literature survey of the use of mf-VEP in optic neuritis (ON) and multiple sclerosis (MS) is presented (38 published studies were retrieved). Mf-VEP provides direct topographical information of specific lesions and facilitates investigations on structural-functional correlations thus providing new methods for exploring the interplay between demyelination, atrophy and remyelination in MS. Good correlation was shown between mf-VEP and OCT, ff-VEP, MRI (MTR, DTI), 30-2 standard automated perimetry and low-contrast-visual acuity. All but one study showed superior sensitivity and specificity compared to ff-VEP, especially with regards to small, peripheral lesions or lesions of the upper visual field. Mf-VEP has shown superior sensitivity and specificity than established methods in diagnosing optic nerve lesions and tracking functional recovery following lesions. Abnormal mf-VEP responses in the fellow, non-ON afflicted eye may predict MS risk in ON patients. No standardization currently exists and no direct comparisons in ON and MS between at least 5 ...Continue Reading

Citations

Feb 14, 2018·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Yael Backner, Netta Levin
Apr 5, 2019·PloS One·Luis de SantiagoLuciano Boquete
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