Multifrequency Dynamics of Cortical Neuromagnetic Activity Underlying Seizure Termination in Absence Epilepsy

Frontiers in Human Neuroscience
Jintao SunXiaoshan Wang

Abstract

This study aimed to investigate the spectral and spatial signatures of neuromagnetic activity underlying the termination of absence seizures. Magnetoencephalography (MEG) data were recorded from 18 drug-naive patients with childhood absence epilepsy (CAE). Accumulated source imaging (ASI) was used to analyze MEG data at the source level in seven frequency ranges: delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (12-30 Hz), gamma (30-80 Hz), ripple (80-250 Hz), and fast ripple (250-500 Hz). In the 1-4, 4-8, and 8-12 Hz ranges, the magnetic source during seizure termination appeared to be consistent over the ictal period and was mainly localized in the frontal cortex (FC) and parieto-occipito-temporal junction (POT). In the 12-30 and 30-80 Hz ranges, a significant reduction in source activity was observed in the frontal lobe during seizure termination as well as a decrease in peak source strength. The ictal peak source strength in the 1-4 Hz range was negatively correlated with the ictal duration of the seizure, whereas in the 30-80 Hz range, it was positively correlated with the course of epilepsy. The termination of absence seizures is associated with a dynamic neuromagnetic process. Frequency-dependent changes in the FC w...Continue Reading

References

Jan 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Roger D TraubMiles A Whittington
May 24, 2008·Neuroscience and Biobehavioral Reviews·Paul Sauseng, Wolfgang Klimesch
May 28, 2008·Epilepsia·Fred A Lado, Solomon L Moshé
Apr 28, 2009·Nature·Jessica A CardinChristopher I Moore
May 29, 2009·Epileptic Disorders : International Epilepsy Journal with Videotape·Jing XiangDouglas Rose
Jul 18, 2009·International Review of Neurobiology·Claudio BabiloniGian Luca Romani
Sep 29, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Christos PapadelisAndreas A Ioannides
Dec 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Anita K RoopunMark O Cunningham
Jan 2, 2010·Journal of Neurosurgery. Pediatrics·Jing XiangTon DeGrauw
Jun 29, 2010·Epilepsy & Behavior : E&B·Jerzy P SzaflarskiScott K Holland
May 3, 2011·Medical & Biological Engineering & Computing·Disha GuptaGilles van Luijtelaar
Sep 29, 2011·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Deok-Soo KimFrank Zelko
Mar 3, 2012·Biological Psychiatry·Vikaas S Sohal
Jun 15, 2013·Epilepsy Research·Jeffrey R TenneyDouglas F Rose
Jun 25, 2013·Brain Topography·Francesca PittauJean Gotman
Dec 26, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Karolin KerberJulia Jacobs
Feb 18, 2014·Journal of Child Neurology·Eliza Jacobs-BrichfordJeffrey R Tenney
Jun 7, 2014·Frontiers in Neuroinformatics·Jing XiangDouglas F Rose
Jun 24, 2014·Neurobiology of Disease·Annika LüttjohannGilles van Luijtelaar
Jul 22, 2014·Annals of Neurology·Jeffrey R TenneyDouglas F Rose
Sep 13, 2014·Current Opinion in Neurobiology·Juhan AruRaul Vicente
Dec 3, 2014·Journal of Neuroscience Methods·Jing XiangElizabeth A Thompson
Jan 8, 2015·Frontiers in Human Neuroscience·Kimberly LeikenXiaoshan Wang
Jul 1, 2015·Frontiers in Human Neuroscience·Yvonne Höller, Eugen Trinka
Sep 20, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Lu TangXiaoshan Wang
Dec 4, 2015·Neuroscience·Marina V SysoevaIlya V Sysoev
Dec 19, 2015·Epilepsy Research·Yvonne J W RozendaalPauly P W Ossenblok
May 26, 2016·Epilepsia·Stefan FuertingerFarid Hamzei-Sichani
Jun 18, 2017·Seizure : the Journal of the British Epilepsy Association·Xavier De TiègeRitva Paetau
Jul 15, 2017·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Vasileios KokkinosGeorge K Kostopoulos

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging technique

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.