Multifunctional and biomimetic fish collagen/bioactive glass nanofibers: fabrication, antibacterial activity and inducing skin regeneration in vitro and in vivo

International Journal of Nanomedicine
Tian ZhouJiao Sun

Abstract

The development of skin wound dressings with excellent properties has always been an important challenge in the field of biomedicine. In this study, biomimetic electrospun fish collagen/bioactive glass (Col/BG) nanofibers were prepared. Their structure, tensile strength, antibacterial activity and biological effects on human keratinocytes, human dermal fibroblasts and human vascular endothelial cells were investigated. Furthermore, the Sprague Dawley rat skin defect model was used to validate their effect on wound healing. The results showed that compared with pure fish collagen nanofibers, the tensile strength of the Col/BG nanofibers increased to 21.87±0.21 Mpa, with a certain degree of antibacterial activity against Staphylococcus aureus. It was also found that the Col/BG nanofibers promoted the adhesion, proliferation and migration of human keratinocytes. Col/BG nanofibers induced the secretion of type one collagen and vascular endothelial growth factor by human dermal fibroblasts, which further stimulated the proliferation of human vascular endothelial cells. Animal experimentation indicated that the Col/BG nanofibers could accelerate rat skin wound healing. This study developed a type of multifunctional and biomimetic fis...Continue Reading

Citations

Apr 30, 2020·Critical Reviews in Food Science and Nutrition·Fazli SubhanFazli Wahid
Aug 14, 2019·Marine Drugs·Ye-Seon LimSik Yoon
Jan 10, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Nilza RibeiroSusana R Sousa
Dec 10, 2020·Materials·Rachele SergiValeria Cannillo
Mar 7, 2021·Marine Drugs·Daniela CoppolaDonatella de Pascale
Apr 10, 2021·Biomacromolecules·Dario FassiniRui L Reis
Aug 3, 2021·Dental Materials Journal·Shizuka YamadaAtsutoshi Yoshimura
Dec 16, 2020·ACS Biomaterials Science & Engineering·Tina MehrabiZahra Mohammadi

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Methods Mentioned

BETA
scanning electron microscopy
X-ray
fluorescence microscopy

Software Mentioned

ImageJ
SPSS

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