Multifunctional and Redox-Responsive Self-Assembled Magnetic Nanovectors for Protein Delivery and Dual-Modal Imaging

ACS Applied Materials & Interfaces
Hong Yu YangDoo Sung Lee

Abstract

Nanoparticle (NP) based model carriers present an emerging strategy for protein delivery. However, constructing a multifunctional nanocarrier with high loading capacity, diagnostic imaging capacity, and controlled release capability is a tremendous challenge for protein delivery systems. Thus, we herein report on the fabrication of redox-responsive magnetic nanovectors (termed RMNs) through self- assembly of Fe3O4 NPs and redox-responsive polymer ligands, which could effectively transport protein and trigger intracellular protein release. These RMNs also exhibited low toxicity, high stability, biocompatibility, and T2-weighted contrast-enhancement properties. In addition, they presented a quantized positively charged surface that had the capacity to load cyanine 5.5 (Cy5.5) labeled human serum albumin (HSA) with high loading efficiency (∼84%) via electrostatic interactions and which favored cellular uptake. Notably, studies of the in vitro protein release showed that HSA-Cy5.5-loaded RMNs (RMNs-HSA-Cy5.5) presented minimal cumulative release behavior under physiological conditions but release was rapidly enhanced under high glutathione concentration conditions. Confocal microscopy further revealed that protein was delivered and...Continue Reading

References

Jan 8, 2004·Journal of the American Chemical Society·Shouheng SunGuanxiong Li
Dec 22, 2007·Nature Reviews. Drug Discovery·Benjamin LeaderDavid E Golan
Jan 6, 2010·Journal of Pharmaceutical Sciences·Dipak S PisalSathy V Balu-Iyer
Sep 22, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Guang Hui GaoDoo Sung Lee
Sep 28, 2010·Advanced Drug Delivery Reviews·Kazuo Maruyama
Nov 6, 2010·International Journal of Offender Therapy and Comparative Criminology·Matt DelisiAnna E Kosloski
Aug 1, 2012·International Journal of Nanomedicine· Wahajuddin, Sumit Arora
May 15, 2013·Cancer Letters·Poornima Budime Santhosh, Nataša Poklar Ulrih
Aug 26, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yue LuZhen Gu
Jan 9, 2015·Pharmaceutical Development and Technology·Muhammad Sajid Hamid AkashShuqing Chen
Apr 22, 2015·ACS Applied Materials & Interfaces·Santanu PatraPrashant K Sharma
Jul 30, 2015·Biomaterials Science·L P Herrera Estrada, J A Champion
Jan 15, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Mahdi KarimiMichael R Hamblin
Jan 19, 2016·Chemical Society Reviews·Mahdi KarimiMichael R Hamblin
Jun 29, 2016·ACS Applied Materials & Interfaces·Mahdi KarimiMichael R Hamblin
Dec 4, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haneen OmarNiveen M Khashab
Feb 14, 2017·Journal of the American Chemical Society·Mahdi KarimiMichael R Hamblin
Jan 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hui Zou, Weizhong Yuan
Dec 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lidi ChenFaquan Yu

❮ Previous
Next ❯

Citations

Mar 15, 2018·Chemical Society Reviews·Federica ScalettiVincent M Rotello
Sep 22, 2018·Advanced Healthcare Materials·Liang ChengZhiyuan Zhong
Sep 23, 2018·Journal of Biomedical Materials Research. Part a·Bing YuHailin Cong
Jan 21, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Huu Thuy Trang DuongDoo Sung Lee
Sep 25, 2020·Expert Opinion on Drug Delivery·Joydeb Majumder, Tamara Minko
Sep 10, 2019·Advanced Materials·Xiaofei QinWei Huang
Oct 15, 2018·Journal of Nanobiotechnology·Muhammad Raisul AbedinSutapa Barua
Sep 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hong Yu YangDoo Sung Lee
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Ting ZhaoHong Yu Yang
Dec 21, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jing MaoJinghua Chen
Mar 27, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Namdev DhasTejal Mehta
Mar 20, 2019·ACS Applied Materials & Interfaces·Huu Thuy Trang DuongDoo Sung Lee
Jun 30, 2018·ACS Applied Materials & Interfaces·Ming LiuZhigang Xie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.