Multifunctional composite hydrogel bolus with combined self-healing, antibacterial and adhesive functions for radiotherapy.

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Yi HouLi Zhang

Abstract

Radiotherapy is a commonly used method for curing cancers that appear on or just below the skin. Because of the dose build-up effect of X-rays, boluses made of various materials such as silica and wax are clinically applied on patients to increase the skin dose for an enhanced therapeutic effect. However, these commercial boluses can't conform well to the skin's surface with some curvature, resulting in radiation dose attenuation/loss at the lesion location. To address this limitation, we have developed a nano-titanium dioxide (nTiO2)-incorporated polyurethane/polyacrylamide (TPU/PAAm) hydrogel with multi-functions for fabricating a desirable bolus. The obtained hydrogel exhibits excellent mechanical, adhesive and self-healing properties and can fit closely to the surface of patients with any 3D curvature, eliminating the air gap which is a common problem for commercial boluses applied on patients. In particular, it is encouraging that when using the bolus made of TPU/PAAm hydrogel, the dose distribution including dose coverage, conformability and homogeneity within the planning target volume (PTV) is far superior to that when using the commercial bolus. A sufficient dose shifts toward the surface of the head model and is locat...Continue Reading

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Citations

Aug 7, 2021·Macromolecular Bioscience·Wenzhen DuPeng Zhang

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Methods Mentioned

BETA
X-ray
infrared spectrometry
differential scanning calorimetry
scanning electron microscopy
optical microscopy

Software Mentioned

Ecipse8

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