Multifunctional degradable electronic scaffolds for cardiac tissue engineering

Journal of Controlled Release : Official Journal of the Controlled Release Society
Ron FeinerTal Dvir

Abstract

The capability to on-line sense tissue function, provide stimulation to control contractility and efficiently release drugs within an engineered tissue microenvironment may enhance tissue assembly and improve the therapeutic outcome of implanted engineered tissues. To endow cardiac patches with such capabilities we developed elastic, biodegradable, electronic scaffolds. The scaffolds were composed of electrospun albumin fibers that served as both a substrate and a passivation layer for evaporated gold electrodes. Cardiomyocytes seeded onto the electronic scaffolds organized into a functional cardiac tissue and their function was recorded on-line. Furthermore, the electronic scaffolds enabled to actuate the engineered tissue to control its function and trigger the release of drugs. Post implantation, these electronic scaffolds degraded, leading to the dissociation of the inorganic material from within the scaffold. Such technology can be built upon to create a variety of degradable devices for tissue engineering of various tissues, as well as pristine cell-free devices with electronic components for short-term in vivo use.

Citations

Mar 7, 2020·Materials·Yuanfen ChenReza Montazami
Dec 20, 2018·Proceedings of the National Academy of Sciences of the United States of America·Ron Feiner, Tal Dvir
Aug 7, 2020·Biosensors·Yi-Chen Ethan Li, I-Chi Lee
Jul 28, 2020·Cardiovascular Engineering and Technology·Evan P TracyRavi K Birla
Dec 16, 2020·ACS Biomaterials Science & Engineering·Suliman KhanMojtaba Falahati
Mar 1, 2019·Nano Letters·LeeRon Shefet CarassoTal Dvir
Sep 29, 2021·Chemical Reviews·Anna MarianoFrancesca Santoro
Dec 16, 2021·Chemical Reviews·Charalampos PitsalidisRóisín M Owens

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Methods Mentioned

BETA
scanning electron microscopy

Software Mentioned

GraphPad Prism
ImageJ
LabView Signal Express
Elements
NIS
GraphPad

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