Multifunctional liposomes delay phenotype progression and prevent memory impairment in a presymptomatic stage mouse model of Alzheimer disease

Journal of Controlled Release : Official Journal of the Controlled Release Society
Simona ManciniFrancesca Re

Abstract

The failure of clinical trials largely focused on mild to moderate stages of Alzheimer disease has suggested to the scientific community that the effectiveness of Amyloid-β (Aβ)-centered treatments should be evaluated starting as early as possible, well before irreversible brain damage has occurred. Accordingly, also the preclinical development of new therapies should be carried out taking into account this suggestion. In the present investigation we evaluated the efficacy of a treatment with liposomes multifunctionalized for crossing the blood-brain barrier and targeting Aβ, carried out on young APP/PS1 Tg mice, taken as a model of pre-symptomatic disease stage. Liposomes were administered once a week to Tg mice for 7months, starting at the age of 5months and up to the age of 12 when they display AD-like cognitive and brain biochemical/anatomical features. The treatment prevented the onset of the long-term memory impairment and slowed down the deposition of brain Aβ; at anatomical level, prevented both ventricle enlargement and entorhinal cortex thickness reduction, otherwise occurring in untreated mice. Strikingly, these effects were maintained 3months after treatment discontinuation. An increase of Aβ levels in the liver was...Continue Reading

Citations

Feb 9, 2018·Protein Science : a Publication of the Protein Society·Wai-Ming Yau, Robert Tycko
Aug 9, 2018·Nanomedicine·Weiyuan ZhangZhiyong He
Jun 12, 2020·Frontiers in Synaptic Neuroscience·Lara Ordóñez-Gutiérrez, Francisco Wandosell
Nov 13, 2019·Journal of Nanobiotechnology·Beatrice FormicolaFrancesca Re
Jan 27, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Maria Inês TeixeiraPaulo C Costa
Aug 17, 2021·Journal of Alzheimer's Disease : JAD·Gianna FoteHoward J Federoff
Feb 25, 2019·Advanced Drug Delivery Reviews·Caroline VissersHongjun Song

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