Multifunctional Liposomes for Image-Guided Intratumoral Chemo-Phototherapy

Advanced Healthcare Materials
Dyego MirandaJonathan F Lovell

Abstract

Intratumoral (IT) drug injections reduce systemic toxicity, but delivered volumes and distribution can be inconsistent. To improve IT delivery paradigms, porphyrin-phospholipid (PoP) liposomes are passively loaded with three hydrophilic cargos: sulforhodamine B, a fluorophore; gadolinium-gadopentetic acid, a magnetic resonance (MR) agent; and oxaliplatin, a colorectal cancer chemotherapeutic. Liposome composition is optimized so that cargo is retained in serum and storage, but is released in less than 1 min with exposure to near infrared light. Light-triggered release occurs with PoP-induced photooxidation of unsaturated lipids and all cargos release concurrently. In subcutaneous murine colorectal tumors, drainage of released cargo is delayed when laser treatment occurs 24 h after IT injection, at doses orders of magnitude lower than systemic ones. Delayed light-triggering results in substantial tumor shrinkage relative to controls a week following treatment, although regrowth occurs subsequently. MR imaging reveals that over this time frame, pools of liposomes within the tumor migrate to adjacent regions, possibly leading to altered spatial distribution during triggered drug release. Although further characterization of cargo ...Continue Reading

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Citations

Jun 25, 2019·Biomaterials Science·Dyego MirandaJonathan F Lovell
Jan 11, 2019·Pharmaceutics·Catarina Oliveira SilvaCatarina Reis
Apr 16, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Miloslav MacháčekJonathan F Lovell
Sep 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alfonso Toro-CordovaPatricia Garcia-Lopez
Sep 25, 2019·International Journal of Molecular Sciences·Ngoc Thuy Trang LeThai Thanh Hoang Thi
May 21, 2019·Biochemical Engineering Journal·Sanjana GhoshJonathan F Lovell
Apr 4, 2021·Acta Biomaterialia·Rui SangWei Deng
Jan 27, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dandan LuoJonathan F Lovell
Jul 3, 2021·Advanced Nanobiomed Research·Sunanda KumarJonathan F Lovell
Feb 1, 2018·Nano Letters·Upendra ChitgupiJonathan F Lovell
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Aug 28, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Hailey I KilianJonathan F Lovell

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