Multifunctional magnetic hairbot for untethered osteogenesis, ultrasound contrast imaging and drug delivery

Biomaterials
Ajay Vikram SinghMetin Sitti

Abstract

To explore novel materials graded for biological functions is one of the grand challenges and ambitions of robotics. In this study, the design, development, and external guidance of micron-sized hair-derived robots (hairbots) are shown as autologous cargo carriers for guided drug delivery, untethered osteogenesis, and sonographic contrast agents. Having biogenic origin, the hairbots show excellent biocompatibility, as demonstrated with cell adhesion, spreading and proliferation. External magnetic fields are used to enhance differentiation of mesenchymal stem cells (MSCs) into bone like cells, which can be used as magnetic therapy for bone healing. Effect of external magnetic forces was simulated by COMSOL Multiphysics® modelling software. The action of hairbots as osteoconductive material triggering osteogenic differentiations of MSCs is studied via calcium signaling by fluorescence microscopy. Further, by exploiting the hollow medullary region, the proposed hairbots are designed to perform theranostic dual functions (therapy + diagnostic) - as Doxorubicin drug delivery vehicle, and for Ultrasound contrast imaging. Harnessing sensing and actuation due to magnetic capabilities of hairbots, for enhanced biological functionality s...Continue Reading

Citations

Oct 4, 2019·Expert Opinion on Drug Delivery·Ajay Vikram SinghAndreas Luch
Nov 14, 2019·Materials·Jordi Caballé-SerranoDieter D Bosshardt
Dec 3, 2020·Micromachines·Ada-Ioana Bunea, Rafael Taboryski
Dec 18, 2020·Advanced Healthcare Materials·Junhee ChoiHongsoo Choi
Dec 19, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Weijia LuYi Qi
Mar 2, 2021·Journal of Drug Targeting·Rakesh K SindhuZakieh Keshavarzi
Apr 1, 2021·Chemical Reviews·Huaijuan ZhouMartin Pumera
Mar 30, 2021·International Journal of Nanomedicine·Shuai BianChunsheng Xiao
Jun 25, 2021·International Journal of Nanomedicine·Yongjia HuangJingqing Zhang
Jul 23, 2021·Advanced Healthcare Materials·Ajay Vikram SinghByung-Wook Park
Aug 11, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lina DongJingjing Li
Sep 2, 2020·ACS Nano·Azaam AzizOliver G Schmidt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Wenjun ChengYan Zhao
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Bing YueKerong Dai
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
Jin-lan JinMin Zhang
© 2021 Meta ULC. All rights reserved