Multifunctional murrel caspase 1, 2, 3, 8 and 9: Conservation, uniqueness and their pathogen-induced expression pattern

Fish & Shellfish Immunology
Venkatesh KumaresanJesu Arockiaraj

Abstract

Caspases are evolutionarily conserved proteases which play fundamental role in apoptosis. Invasion of pathogen triggers the activation of caspases-mediated pro-inflammatory and pro-apoptotic pathways, where multifunctional caspases are involved. In striped murrel Channa striatus, epizootic ulcerative syndrome (EUS) causes endemics resulting in huge economic loss. Aphanomyces invadans, an oomycete is the primary causative agent of EUS which further induces secondary bacterial infections especially Aeromonas hydrophila. In order to get insights into the caspase gene family in C. striatus during EUS infection, we performed various physicochemical and structural analyses on the cDNA and protein sequences of five different murrel caspases namely CsCasp 1, 2, 3, 8 and 9. Sequence analysis of murrel caspase proteins showed that in spite of the conserved CASC domain, each caspase embraces some unique features which made them functionally different. Tissue distribution analysis showed that all the murrel caspases are highly expressed in one of the immune organs such as liver, kidney, spleen and blood cells. Further, to understand the role of caspase during EUS infection, modulation in expression of each caspase gene was analysed after i...Continue Reading

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Citations

Jun 2, 2016·Fish & Shellfish Immunology·Yina ShaoQiongfen Qiu
Jan 28, 2017·Developmental and Comparative Immunology·Abirami ArasuJesu Arockiaraj
Mar 8, 2020·Lipids in Health and Disease·Meseret Derbew MollaTesfahun Dessale Admasu
May 1, 2021·International Journal of Molecular Sciences·Natsuki MorimotoJun-Ichi Hikima
Aug 25, 2017·International Journal of Biological Macromolecules·Gayathri RavichandranJesu Arockiaraj
Apr 12, 2018·Environmental Science & Technology·Tingting ChaiXingquan Liu

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