Multifunctional nanocomposites of superparamagnetic (Fe3O4) and NIR-responsive rare earth-doped up-conversion fluorescent (NaYF4 : Yb,Er) nanoparticles and their applications in biolabeling and fluorescent imaging of cancer cells.

Nanoscale
Cong-Cong MiShu-Kun Xu

Abstract

A new kind of magnetic/luminescent multifunctional nanoparticles was synthesized by covalently linking multiple carboxyl-functionalized superparamagnetic Fe(3)O(4) nanoparticles and individual amino-functionalized silica-coated fluorescent NaYF(4) : Yb,Er up-conversion nanoparticles (UCNPs). The resultant nanocomposites bear active carboxylic and amino groups on the surface that were proved to be chemically active and useful for further facile bioconjugation with biomolecules. The UCNPs in the nanocomposite particles can emit visible light in response to the irradiation by near infrared (NIR) light, enabling the application of the nanocomposites in bioimaging. X-Ray diffraction, infrared spectroscopy, transmission electron microscopy, luminescence spectroscopy, and magnetometry were applied to characterize the multifunctional nanocomposites. The nanocomposites exhibited good superparamagnetic and excellent green up-conversion photoluminescent properties that can be exploited in magnetic separation and guiding as well as bioimaging. Due to the presence of active functional groups on the nanocomposite surface, the Fe(3)O(4)/NaYF(4) : Yb,Er magnetic/luminescent nanocomposites were successfully conjugated with a protein called tran...Continue Reading

References

Jan 15, 2004·Chemical Reviews·François Auzel
Jan 13, 2005·Journal of the American Chemical Society·Hyungrak KimVictor I Klimov
Jan 13, 2006·Nano Letters·Dinna G RamlanLincoln J Lauhon
Jul 12, 2007·Chemical Communications : Chem Comm·Xun Wang, Yadong Li
Sep 18, 2007·Analytical Biochemistry·Ahjeong SonKrassimira R Hristova
Oct 31, 2007·Journal of Biomedical Materials Research. Part a·Ying ZhangZhi-Dong Zhang
Mar 5, 2008·Journal of the American Chemical Society·Jinhao GaoBing Xu
Apr 24, 2008·Journal of Colloid and Interface Science·Bingbo ZhangJin Chang
Jul 26, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Masao KamimuraYukio Nagasaki
Feb 12, 2009·ACS Nano·Oliver EhlertThomas Nann
May 30, 2009·Accounts of Chemical Research·Jinhao GaoBing Xu
Jul 2, 2009·Chemical Communications : Chem Comm·Zhi-Quan TianDai-Wen Pang

❮ Previous
Next ❯

Citations

Aug 23, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Cuie WangShou-Jun Xiao
Jul 11, 2013·Nanoscale Research Letters·Valentin A MilichkoVladimir P Dzyuba
Jul 13, 2011·International Journal of Molecular Sciences·Juan L Vivero-Escoto, Yu-Tzu Huang
Oct 23, 2012·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Marcin RunowskiStefan Lis
Dec 26, 2015·Analytical Chemistry·Andreas SedlmeierHans H Gorris
Dec 9, 2015·ACS Nano·Magdiel I SetyawatiDavid T Leong
Jan 23, 2016·Chemical Reviews·Guanying ChenParas N Prasad
Aug 5, 2015·Chemical Society Reviews·Magdiel Inggrid SetyawatiDavid Tai Leong
Oct 15, 2013·Advanced Drug Delivery Reviews·Numfon KhemthongcharoenWibool Piyawattanametha
Mar 23, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Meng WangShukun Xu
Dec 25, 2010·Chemical Society Reviews·Luís D CarlosPurificación Escribano
May 18, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Bin DuJie Zhou
Aug 9, 2016·Chemical Reviews·Rachel D HarrisEmily A Weiss
Nov 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ahmed O ElzoghbyMay S Freag
Jul 7, 2012·Journal of Materials Chemistry·Hongyu ChenJeffrey N Anker
Sep 21, 2016·Journal of Drug Targeting·Nazanin RahmanianYadollah Omidi
Jul 29, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·K C BarickP A Hassan
Mar 31, 2015·Beilstein Journal of Nanotechnology·Shanka Walia, Amitabha Acharya
Jan 11, 2020·Chemistry : a European Journal·Huayna TerraschkeClaudia Wickleder
Mar 25, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Zhenzhen LiQiang Zhao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.