Multifunctional nanoprobes for both fluorescence and 19 F magnetic resonance imaging

Nanoscale
Chang GuoLeyu Wang

Abstract

Fluorescence is widely used for cell imaging due to its high sensitivity and rich color choice but limited for in vivo imaging because of its low light penetration. Meanwhile, magnetic resonance imaging (MRI) is widely applied for in vivo diagnosis but not suitable for cell imaging because of its low resolution. Compared to 1H-MRI, 19F-MRI is more suitable for clinical application due to its high sensitivity but fabricating 19F-MRI probes is a great challenge. Therefore, it is highly desirable to develop a dual-modal imaging probe for both cell fluorescence imaging and in vivo19F-MRI with high sensitivity and deep penetration. In this study, 19F moiety loaded nanocomposites with an organic fluorescent core were successfully prepared via a facile strategy by encapsulating organic dyes with oleylamine-functionalized polysuccinimide and 1H,1H,2H,2H-perfluorodecyltriethoxysilane (PDTES). The aggregation of organic fluorescent dyes in the core results in significant fluorescence for optical imaging, while the 19F moieties on PDTES allow for simultaneous 19F MRI. Moreover, the nanocomposites exhibited high water dispersibility and excellent biocompatibility. These properties make them promising for both cell imaging and in vivo imagi...Continue Reading

References

Mar 16, 2005·Nature Neuroscience·Makoto HiguchiTakaomi C Saido
Jul 26, 2005·Nature Biotechnology·Eric T AhrensPenelope A Morel
Dec 25, 2007·Journal of the American Chemical Society·Shin MizukamiKazuya Kikuchi
Apr 9, 2009·Angewandte Chemie·Shin MizukamiKazuya Kikuchi
Nov 12, 2010·Physical Chemistry Chemical Physics : PCCP·Nikhil R Jana
Dec 4, 2012·Chemical Communications : Chem Comm·Qiongqiong WanHuimin Ma
Oct 21, 2014·Chemical Reviews·Ilaria TirottaGiuseppe Resnati
Dec 23, 2015·Analytical Chemistry·Shiguo WangLeyu Wang
Sep 2, 2016·Accounts of Chemical Research·Fei MaChun-Yang Zhang
Oct 28, 2016·Chemical Communications : Chem Comm·Qian WangYun-Bao Jiang
Dec 9, 2016·Chemical Communications : Chem Comm·Dan-Dan TaoYun-Bao Jiang

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Citations

Mar 30, 2018·Chemical Communications : Chem Comm·Shaowei BoZhong-Xing Jiang
Aug 17, 2018·Chemical Communications : Chem Comm·Chang GuoLeyu Wang
Oct 12, 2021·Analytical Chemistry·Chang GuoLeyu Wang
Oct 28, 2021·Chemistry : a European Journal·Dawid Janasik, Tomasz Krawczyk

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