Multifunctional network-structured film coating for woven and knitted polyethylene terephthalate against cardiovascular graft-associated infections

International Journal of Pharmaceutics
Bassam Al MeslmaniUdo Bakowsky

Abstract

Multifunctional network-structured polymeric coat for woven and knitted forms of crimped polyethylene terephthalate PET graft was developed to limit graft-associated infections. A newly synthesized antibacterial sulfadimethoxine polyhexylene adipate-b-methoxy polyethylene oxide (SD-PHA-b-MPEO) di-block copolymer was employed. Our figures of merit revealed that the formed coat showed a porous topographic architecture which manifested paramount properties, mostly bacterial anti-adhesion efficiency and biocompatibility with host cells. Compared to untreated grafts, the coat presented marked reduction of adhered Gram-positive Staphylococcus epidermidis previously isolated from a patient's vein catheter by 2.6 and 2.3 folds for woven and knitted grafts, respectively. Similarly, bacterial anti-adhesion effect was observed for Staphylococcus aureus by 2.3 and 2.4 folds, and by 2.9 and 2.7 folds for Gram-negative Escherichia coli for woven and knitted grafts, respectively. Additionally, adhesion and growth characteristics of L929 cells on the modified grafts revealed no significant effect on the biocompatibility. In conclusion, coating of PET with (SD-PHA-b-MPEO) is a versatile approach offers the desired bacterial anti-adhesion effect...Continue Reading

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Sep 2, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Bassam Al MeslmaniUdo Bakowsky

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Citations

Jan 24, 2017·Experimental Biology and Medicine·Erika L Cyphert, Horst A von Recum
Feb 11, 2020·Medical Microbiology and Immunology·Tugçe ÇaykaraCarla Joana Silva

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