Multifunctional theranostic nanoplatform for cancer combined therapy based on gold nanorods

Advanced Healthcare Materials
Wei-Hai ChenXian-Zheng Zhang

Abstract

Nanomaterials that integrate diagnostic and therapeutic functions within a single nanoplatform promise great advances in revolutionizing cancer therapy. A smart multifunctional theranostic drug-delivery system (DDS) based on gold nanorods (abbreviated as GNR/TSDOX) is designed for cancer-targeted imaging and imaging-guided therapy. In this intelligent theranostic DDS, the active targeting ligand biotin is introduced to track cancer sites in vivo. With the aid of photothermal/photoacoustic imaging, GNR/TSDOX can ablate cancer specifically and effectively. When stimulated with a single near-infrared (NIR) light source, this NIR light energy is effectively absorbed and converted into heat by GNR/TSDOX for localized photothermal therapy and the increase in temperature also further triggers the cascaded release of the anticancer drug for combined thermo-chemotherapy. More importantly, the in vivo cure effect can be well guided by regulating the irradiation time and intensity of the NIR light.

References

Feb 9, 2006·Journal of the American Chemical Society·Xiaohua HuangMostafa A El-Sayed
Jun 24, 2006·Nature Reviews. Cancer·Ana P CastanoMichael R Hamblin
Mar 18, 2009·Journal of the American Chemical Society·Akamol KlaikherdS Thayumanavan
Apr 16, 2009·Cancer Research·Geoffrey von MaltzahnSangeeta N Bhatia
Nov 17, 2009·Advanced Drug Delivery Reviews·Omid VeisehMiqin Zhang
Sep 23, 2010·Advanced Drug Delivery Reviews·Prakash RaiTayyaba Hasan
Jul 2, 2011·Nanomedicine·Jesse V JokerstSanjiv S Gambhir
Aug 19, 2011·Accounts of Chemical Research·Marites P MelanconChun Li
Oct 12, 2011·Journal of the American Chemical Society·Jin-Zhi DuJun Wang
Mar 17, 2012·Journal of the American Chemical Society·Limin PanJianlin Shi
Jun 29, 2012·Advanced Materials·Leonid VigdermanEugene R Zubarev
Nov 7, 2012·Chemical Society Reviews·Huanjun ChenJianfang Wang
Mar 9, 2013·Theranostics·Jyothi U MenonKytai T Nguyen
Sep 21, 2013·Advanced Materials·Zhenjiang ZhangChunying Chen
Oct 24, 2013·Nature Materials·Simona MuraPatrick Couvreur
Mar 13, 2014·Nature Communications·Ran MoZhen Gu
Mar 20, 2014·Angewandte Chemie·Sankarprasad BhuniyaJong Seung Kim
Apr 30, 2014·Journal of the American Chemical Society·Zhenjiang ZhangChunying Chen
May 9, 2014·Chemical Communications : Chem Comm·Carmen Alvarez-Lorenzo, Angel Concheiro
Jun 27, 2014·Chemical Society Reviews·Liming Nie, Xiaoyuan Chen
Sep 27, 2014·Chemical Reviews·Liang ChengZhuang Liu
Oct 21, 2014·Chemical Communications : Chem Comm·Wei-Hai ChenXian-Zheng Zhang
Dec 28, 2009·Advanced Materials·Xiaohua HuangMostafa A El-Sayed

❮ Previous
Next ❯

Citations

Jan 27, 2017·ACS Applied Materials & Interfaces·Yi YiWeihong Tan
Jan 16, 2018·Advanced Healthcare Materials·Zhao-Hua MiaoCheng-Yan Xu
Feb 23, 2019·Nanomedicine·Bankuru Navyatha, Seema Nara
Mar 12, 2019·Advanced Healthcare Materials·Qingxin MuMiqin Zhang
Apr 26, 2019·Beilstein Journal of Nanotechnology·Boris Nikolayevich KhlebtsovNikolai G Khlebtsov
Aug 31, 2019·Biomedical Optics Express·L A Dykman, N G Khlebtsov
Sep 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zihnil Adha Islamy MazradSung Young Park
May 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chen WangPiaoping Yang
Sep 28, 2018·Advanced Materials·Wei-Hai ChenXian-Zheng Zhang
Dec 6, 2019·Frontiers in Bioengineering and Biotechnology·Yu YangXinxin Li
Oct 28, 2018·Journal of Colloid and Interface Science·Xin WangZhigang Xie
Jan 10, 2021·Pharmaceutics·Daniela Placha, Josef Jampilek
Dec 14, 2017·ACS Applied Materials & Interfaces·Shuwei LiuHao Zhang
Mar 10, 2017·ACS Applied Materials & Interfaces·Rajendra K SinghHae-Won Kim
Apr 12, 2017·ACS Applied Materials & Interfaces·Panchanathan ManivasaganJunghwan Oh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.