Multifunctional Ti-(Ca,Zr)-(C,N,O,P) films for load-bearing implants

Biomaterials
D V ShtanskyEvgeny A Levashov

Abstract

Films of Ti-Ca-P-C-O-(N), Ti-Ca-C-O-(N) and Ti-Zr-C-O-(N) were deposited by DC magnetron sputtering or ion implantation-assisted magnetron sputtering of composite targets TiC0.5 + 10%Ca10(PO4)6(OH)2, TiC0.5 + 20%(CaO + TiO2) and TiC0.5 + 10%ZrO2 in an Ar atmosphere or reactively in a gaseous mixture of Ar + 14%N2. The microstructure, elemental and phase composition of films were studied by means of X-ray diffraction, transmission electron microscopy, scanning force microscopy, X-ray photoelectron spectroscopy and energy-dispersive X-ray spectroscopy. The films were characterized in terms of their hardness, Young's modulus, elastic recovery, adhesion strength, and friction and wear both in air and under physiological solution. Particular attention was paid to the analysis of deformation and fracture for various film/substrate systems during scratch testing. The biocompatibility of the films was evaluated by both in vitro and in vivo experiments. In vitro studies involved the investigation of adhesion, spreading, and proliferation of MC3T3-E1 osteoblasts and IAR-2 epithelial cells, morphometric analysis, actin cytoskeleton, focal contacts staining, alkaline phosphatase activity and von Kossa staining of osteoblastic culture. Cell...Continue Reading

Citations

Apr 24, 2008·Doklady. Biochemistry and Biophysics·D V ShtanskyN A Gloushankova
Aug 15, 2014·International Journal of Molecular Sciences·Jiri GalloCalin S Moucha
Oct 16, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·I V SukhorukovaD V Shtansky
May 24, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Vadim SheremetyevVladimir Brailovski

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