PMID: 7539214May 1, 1995Paper

Multifunctional transporter models: lessons from the transport of water, sugars, and ring compounds by GLUTs

The American Journal of Physiology
J Fischbarg, J C Vera

Abstract

Facilitative glucose transporters (GLUTs) have recently been shown to be multifunctional, transporting substrates other than sugars, such as water and ring compounds as large as nitrobenzene-diazol-aminoglucose. Other membrane proteins, including transporters and cystic fibrosis transmembrane conductance regulator, have also revealed a finite permeability to water. We compare the alpha-helical and beta-barrel models for the structure of GLUTs, discuss recent evidence, and argue that a beta-barrel fold explains it better. We show a model for GLUTs consisting of a relatively rigid beta-barrel translocation unit ("channel") of diameter ample enough to allow permeation of the above substrates (approximately 20 A) but gated shut by mobile loops at both ends. Such gates would open only after aromatic interactions would lead to binding of the ring substrates for GLUTs; water would, however, traverse crevices in the closed gates. Using the insights gained from GLUTs, we propose that other transporters may share with GLUTs the motif of a beta-barrel channel and would be permeable to water due to the presence of such channels together with similarly behaving gates.

References

Dec 1, 1975·Journal of Cellular Physiology·L LackoP Geck
Jan 1, 1992·International Review of Cytology·H R Kaback
May 21, 1992·Nature·S ChoeD Eisenberg
Oct 1, 1991·Pflügers Archiv : European journal of physiology·J A DempsterC H van Os
Oct 1, 1990·Physiological Reviews·A Carruthers
Jun 20, 1990·Journal of Molecular Biology·R HendersonK H Downing
Mar 1, 1990·Diabetes Care·G I BellS Seino
May 5, 1989·Journal of Molecular Biology·R F GeeverN H Giles
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J FischbargJ Loike
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J J ChinC Y Jung
Sep 6, 1985·Science·M MuecklerH F Lodish
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·M EchevarriaG Frindt
Nov 23, 1994·Molecular and Cellular Biochemistry·J FischbargM Garner
Sep 1, 1994·Nature Structural Biology·P GhoshR M Stroud
Jun 1, 1993·The Journal of General Physiology·M EchevarriaE E Windhager
Dec 1, 1993·The Journal of Membrane Biology·A E Hill, B Shachar-Hill
Oct 15, 1993·The Biochemical Journal·G W Gould, G D Holman
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C BondyP Agre

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Citations

Jul 12, 2002·American Journal of Physiology. Renal Physiology·Raymond Quigley, Michel Baum
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Eain M Cornford, Shigeyo Hyman
Jun 28, 2000·Yeast·V LaizéS Hohmann
Feb 4, 2006·Circulation Research·Rahul KakkarElizabeth M McNally
Sep 21, 2013·American Journal of Physiology. Renal Physiology·Jurgen SchnermannDiane Mizel
Apr 5, 2000·Biochimica Et Biophysica Acta·S DelrotL Maurousset
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Markus RitterHubert H Kerschbaum

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