Multifunctional zeolitic imidazolate framework-8 for real-time monitoring ATP fluctuation in mitochondria during photodynamic therapy

Nanoscale
Ke WangChengxiao Zhang

Abstract

Zeolitic imidazolate framework-8 (ZIF-8) is emerging as a promising vector in encapsulation and delivery of imaging agents or drugs. Adenosine triphosphate (ATP) is the primary energy source in cells and plays a key role in many cellular processes. Although numerous probes have been developed for ATP detection, only a few of them were used to real-time monitor ATP fluctuation in mitochondria during photodynamic therapy (PDT). Here, an ATP-responsive and fluorescent ZIF-8 is synthesized for real-time monitoring mitochondrial ATP fluctuation in living cells during photodynamic therapy. Rhodamine B (RhB) as a fluorescent indicator is encapsulated into ZIF-8 to form multifunctional RhB@ZIF-8 via a one step process. RhB@ZIF-8 can rapidly respond to ATP with ZIF-8 decomposition and fluorescence off-on switch via a competitive coordination interaction and exhibits good sensitivity and selectivity to ATP with a detection limit of 35 μM. Furthermore, RhB@ZIF-8 is successfully utilized for real-time monitoring and imaging mitochondrial ATP fluctuation in living cells during photodynamic therapy with good biocompatibility and high cell permeability. It is found that the ATP levels in mitochondria increased within 1 min of light irradiatio...Continue Reading

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Citations

May 13, 2021·Chemical Communications : Chem Comm·Yu-Peng ZhangDai-Wen Pang
Nov 18, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Peng YangHonglan Qi

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Methods Mentioned

BETA
biosensing
scanning
X-ray
Fluorescence

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