Jul 25, 2009

Multifunctionality of extracellular and cell surface heparan sulfate proteoglycans

Cellular and Molecular Life Sciences : CMLS
Catherine B Kirn-SafranDaniel D Carson

Abstract

Heparan sulfate proteoglycans are a remarkably diverse family of glycosaminoglycan-bearing protein cores that include the syndecans, the glypicans, perlecan, agrin, and collagen XVIII. Members of this protein class play key roles during normal processes that occur during development, tissue morphogenesis, and wound healing. As key components of basement membranes in organs and tissues, they also participate in selective filtration of biological fluids, in establishing cellular barriers, and in modulation of angiogenesis. The ability to perform these functions is provided both by the features of the protein cores as well as by the unique properties of heparan sulfate, which is assembled as a polymer of N-acetylglucosamine and glucuronic acid and modified by specific enzymes to generate specialized biologically active structures. This article discusses the structures and functions of this amazing family of proteoglycans and provides a platform for further study of the individual members.

  • References141
  • Citations48

References

  • References141
  • Citations48

Citations

Mentioned in this Paper

Glypican
Filtration
Extracellular
Angiogenic Process
Glycosaminoglycans
Enzymes, antithrombotic
Proteoglycan
Collagen Type XVIII
Extracellular Space
Tumor Angiogenesis

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