Multigene Testing for Hereditary Cancer: When, Why, and How

Journal of the National Comprehensive Cancer Network : JNCCN
Kenneth Offit

Abstract

Multigene testing is a complicated area, with advantages and disadvantages of testing for hereditary cancer syndromes. Currently, NCCN does not endorse routing multiplex testing outside of a research setting, and/or intensive genetic counseling regarding risks and benefits. The 2017 NCCN Clinical Practice Guidelines in Oncology for Genetic/Familial High-Risk Assessment: Breast and Ovarian and Colorectal provide suggestions for mutation carriers identified by panel tests.

Citations

Feb 23, 2019·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Vignesh RavichandranJoseph Vijai
Mar 13, 2018·Journal of the National Cancer Institute·Hormuzd A KatkiMaria Isabel Achatz
Dec 27, 2018·PLoS Genetics·Melissa S ClineAmanda B Spurdle
Jan 30, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ana F BestHormuzd A Katki

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