Multigenerational effects of parental prenatal exposure to famine on adult offspring cognitive function

Scientific Reports
Jie LiYing Li

Abstract

The effects of prenatal nutrition on adult cognitive function have been reported for one generation. However, human evidence for multigenerational effects is lacking. We examined whether prenatal exposure to the Chinese famine of 1959-61 affects adult cognitive function in two consecutive generations. In this retrospective family cohort study, we investigated 1062 families consisting of 2124 parents and 1215 offspring. We assessed parental and offspring cognitive performance by means of a comprehensive test battery. Generalized linear regression model analysis in the parental generation showed that prenatal exposure to famine was associated with a 8.1 (95% CI 5.8 to 10.4) second increase in trail making test part A, a 7.0 (1.5 to 12.5) second increase in trail making test part B, and a 5.5 (-7.3 to -3.7) score decrease in the Stroop color-word test in adulthood, after adjustment for potential confounders. In the offspring generation, linear mixed model analysis found no significant association between parental prenatal exposure to famine and offspring cognitive function in adulthood after adjustment for potential confounders. In conclusion, prenatal exposure to severe malnutrition is negatively associated with visual- motor ski...Continue Reading

References

Mar 1, 1991·Psychological Bulletin·C M MacLeod
Apr 1, 1990·Controlled Clinical Trials·W D Dupont, W D Plummer
Mar 1, 1986·Developmental Psychobiology·P J RogersJ L Smart
Nov 17, 1972·Science·Z SteinF Marolla
Feb 1, 1970·Behaviour Research and Therapy·K R Mitchell, R J Ingham
Mar 1, 1969·Pediatric Research·M Winick, P Rosso
Feb 11, 1998·American Journal of Epidemiology·M SandersonD E Moore
Nov 5, 1999·Nature Genetics·H D MorganE Whitelaw
Nov 24, 1999·Journal of the International Neuropsychological Society : JINS·A S Chan, M W Poon
Dec 22, 1999·BMJ : British Medical Journal·V Smil
Jun 30, 2000·The American Journal of Psychiatry·H E Hulshoff PolR S Kahn
Jul 13, 2000·Journal of Epidemiology and Community Health·M KempS Frankel
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Vardhman K RakyanEmma Whitelaw
Apr 17, 2003·American Journal of Epidemiology·Sunmin LeeFrancine Grodstein
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nitin GogtayPaul M Thompson
Aug 4, 2005·JAMA : the Journal of the American Medical Association·David St ClairLin He
Aug 13, 2005·Neuroscience and Biobehavioral Reviews·Anja C Huizink, Eduard J H Mulder
Oct 19, 2006·Neuroepidemiology·Clinton B WrightRalph L Sacco
Apr 5, 2007·Nature Protocols·Christopher R Bowie, Philip D Harvey
Oct 9, 2009·Alzheimer Disease and Associated Disorders·Qihao GuoZhen Hong
Sep 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Susanne R de RooijTessa J Roseboom
Jan 12, 2011·Annual Review of Public Health·L H LumeyEzra Susser
Jan 21, 2011·International Journal of Epidemiology·Renate Hm de GrootLh Lumey
Jan 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Iwa Antonow-SchlorkeThomas J McDonald
May 7, 2011·Journal of Hypertension·Yanping LiGuansheng Ma
Aug 27, 2011·Experimental Neurology·Mary TolcosSandra Rees
Feb 1, 2012·Nature Reviews. Genetics·Lucia Daxinger, Emma Whitelaw
Feb 24, 2012·Nature Reviews. Molecular Cell Biology·Constance Alabert, Anja Groth
Apr 10, 2012·Central Nervous System Agents in Medicinal Chemistry·Jan Krzysztof Blusztajn, Tiffany J Mellott
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Matthew SudermanMoshe Szyf
Jan 18, 2013·Science Translational Medicine·Jillian VinallSteven P Miller
Jun 29, 2013·The American Journal on Addictions·Samuel R ChamberlainJon E Grant
Jul 6, 2013·Science·Ryan ListerJoseph R Ecker
Apr 2, 2014·Nutrition Reviews·Elizabeth L Prado, Kathryn G Dewey
May 29, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Fuli HeMihai D Niculescu

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Citations

Apr 27, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Catherine E AikenSusan E Ozanne
Apr 26, 2018·International Journal of Environmental Research and Public Health·Alexandra MoraruJean-Marie Degryse
Nov 11, 2017·International Journal of Epidemiology·Hongwei XuJinyu Liu
Apr 13, 2019·Journal of Clinical Medicine·Hongguo RongHai Fang
Aug 30, 2020·Journal of Epidemiology and Community Health·Hongguo RongHai Fang
Oct 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Qu ChengJustin V Remais
Nov 29, 2020·BMC Biology·Joanna RutkowskaShinichi Nakagawa
May 15, 2021·European Journal of Clinical Nutrition·Tianshu HanYing Li
May 15, 2021·European Journal of Clinical Nutrition·Chihua Li, Zhenwei Zhou

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