PMID: 9650573Jul 3, 1998Paper

Multigenerational study of the effects of consumption of PCB-contaminated carp from Saginaw Bay, Lake Huron, on mink. 3. Estrogen receptor and progesterone receptor concentrations, and potential correlation with dietary PCB consumption

Journal of Toxicology and Environmental Health. Part a
E B ShippW G Helferich

Abstract

Mink (Mustela vison) were fed diets containing ocean fish (control diet, 0.0 ppm polychlorinated biphenyls, PCBs) or Saginaw Bay carp to provide 0.25, 0.5, or 1.0 ppm PCBs to examine the effect of PCBs on homeostasis of binding sites for ovarian steroid hormones. Ranch-raised mink fed Great Lakes fish contaminated with PCBs, or treated with PCBs directly, have demonstrated reproductive impairment including anovulation, fetal resorption, delayed ovulation, increased gestation, and decreased litter size. Previous studies have demonstrated that estrogen and progesterone levels are unaltered in mink treated with PCBs, suggesting that the effect of PCBs on reproduction is not mediated through alterations in hormone homeostasis. In vitro studies have demonstrated that the most likely means by which PCBs exert antiestrogenic ability is through a down-regulation of the estrogen receptor in normally estrogen-responsive tissues such as liver and uterus. Hepatic and uterine estrogen binding site concentrations were measured in female mink consuming diets containing PCBs for up to 18 mo at up to 1 ppm. Hepatic estrogen binding site concentrations generally decreased with increasing dietary PCB concentrations. Uterine estrogen binding site ...Continue Reading

Citations

Dec 14, 2004·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Guillermo A Blanco, Edwin L Cooper
Nov 9, 2001·Journal of Toxicology and Environmental Health. Part a·R KäkeläJ Asikainen
Dec 14, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Paola PocarVitaliano Borromeo
Sep 2, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Sharon E HookJack W Anderson
Dec 7, 2007·Ecotoxicology and Environmental Safety·A L BlankenshipJ P Giesy
May 24, 2006·Environmental Research·Niladri BasuHing Man Chan
Feb 29, 2020·Archives of Environmental Contamination and Toxicology·G M TroisiM Nyman

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