PMID: 7024660Jan 1, 1981Paper

Multihormonal control of enzyme clusters in rat liver ontogenesis. II. Role of glucocorticosteroid and thyroid hormone and of glucagon and insulin

Mechanisms of Ageing and Development
Wouter H Lamers, P G Mooren

Abstract

The role of glucocorticosteroid and thyroid hormone and of glucagon and insulin in the pre- and postnatal developmental formation of carbamoyl-phosphate synthase, ornithine transcarbamoylase, arginase, glutamate dehydrogenase, tyrosine aminotransferase, glucose-6-phosphatase, hexokinase and glucokinase activities in rat liver was investigated. Glucocorticosteroids and a low insulin/glucagon ratio always stimulate formation of carbamoyl-phosphate synthase, ornithine transcarbamoylase, arginase, glutamate dehydrogenase, tyrosine aminotransferase and glucose-6-phosphatase, while glucocorticosteroids and a high insulin/glucagon ratio stimulate formation of glucokinase. Thyroid hormone stimulates the formation of carbamoyl-phosphate synthase, arginase and tyrosine aminotransferase only before birth, whereas it stimulates the formation of glutamate dehydrogenase and glucose-6-phosphatase both before and after birth. Ornithine transcarbamoylase activity is depressed after thyroid-hormone treatment before and after birth. DNA content is always decreased by glucocorticosteroids and increased by thyroid hormone. The effect of these hormones on hexokinase is complex, probably due to different responses of the constitutive isozymes. With t...Continue Reading

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Citations

Nov 1, 1985·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·W H LamersR Charles
Jan 1, 1981·Mechanisms of Ageing and Development·W H Lamers, P G Mooren
Dec 1, 1992·Comparative Biochemistry and Physiology. Comparative Physiology·Z J Penefsky, E Diamond
Jan 18, 2014·Neurochemical Research·Cleanthe SpanakiAndreas Plaitakis
May 1, 1994·Differentiation; Research in Biological Diversity·M A DingemanseW H Lamers
Oct 10, 1982·The Journal of Experimental Zoology·W H LamersA de Graaf
Sep 28, 2000·The Journal of Biological Chemistry·V M ChristoffelsW H Lamers
Jul 1, 1986·The American Journal of Physiology·W H LamersR Charles
Apr 29, 1987·Biochimica Et Biophysica Acta·C J de GrootW H Lamers

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