Multilevel analysis of systolic blood pressure and ACE gene I/D polymorphism in 438 Swedish families--a public health perspective

BMC Medical Genetics
Juan MerloOlle Melander

Abstract

Individuals belonging to the same family share a number of genetic as well as environmental circumstances that may condition a common SBP level. Among the genetic factors, the angiotensin converting enzyme (ACE) gene I/D polymorphism appears as a possible candidate as it might influence both SBP and the pharmacological effect of ACE inhibitors. We aimed to combine genetic epidemiology with public health ideas concerning life-course and multilevel epidemiology in order to understand the role of familial factors regarding individual SBP. We applied multilevel regression analysis on 1926 individuals nested within 438 families from South Sweden. Modelling familial SBP variance as a function of age and use of ACE inhibitors we calculates a variance partition coefficient and the proportional change in familial SBP variance attributable to differences in ACE gene I/D polymorphism Our results suggest the existence of genetic or environmental circumstances that produce a considerable familial clustering of SBP, especially among individuals using ACE-inhibitors. However, ACE gene I/D polymorphism seems to play a minor role in this context. In addition, familial factors--genetic, environmental or their interaction--shape SBP among non-use...Continue Reading

References

May 11, 1991·Lancet·L Råstam, G Sjönell
Oct 1, 1993·PCR Methods and Applications·V ShanmugamB K Saha
Jan 1, 1993·Journal of Internal Medicine·G BerglundS A Larsson
Apr 6, 2000·International Journal of Epidemiology·S Greenland
Jan 9, 2003·Pharmacogenomics·Stephen T Turner, Eric Boerwinkle
Jun 25, 2003·Journal of Epidemiology and Community Health·N Malats, F Calafell
Jan 31, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Michel E SafarAnathase Benetos
Feb 21, 2004·BMC Genetics·Laurent BriollaisUNKNOWN Framingham Heart Study
Jun 4, 2004·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Gary L Schwartz, Stephen T Turner
May 9, 2008·Journal of Neuroendocrinology·G GrassiG Mancia

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

MLwiN

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

© 2021 Meta ULC. All rights reserved