Multilevel Regulation and Translational Switches in Synthetic Biology

IEEE Transactions on Biomedical Circuits and Systems
Margarita B KopniczkyPaul S Freemont

Abstract

In contrast to the versatility of regulatory mechanisms in natural systems, synthetic genetic circuits have been so far predominantly composed of transcriptionally regulated modules. This is about to change as the repertoire of foundational tools for post-transcriptional regulation is quickly expanding. We provide an overview of the different types of translational regulators: protein, small molecule and ribonucleic acid (RNA) responsive and we describe the new emerging circuit designs utilizing these tools. There are several advantages of achieving multilevel regulation via translational switches and it is likely that such designs will have the greatest and earliest impact in mammalian synthetic biology for regenerative medicine and gene therapy applications.

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Citations

Oct 22, 2016·ACS Synthetic Biology·Andrea MartellaYizhi Cai
Jan 27, 2017·Microbial Biotechnology·Alexander J WebbPaul S Freemont
Dec 29, 2017·Advanced Healthcare Materials·Christophe BossUmberto De Marchi
Jul 15, 2020·Chemical Communications : Chem Comm·Paolo BollellaEvgeny Katz
Oct 11, 2017·Scientific Reports·Tai-Yin Chiu, Jie-Hong R Jiang
Nov 15, 2016·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Peter KaragiannisHirohide Saito

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