Abstract
Osteoporosis is a common disease with multiple environmental and genetic risk factors involved. Using a marker-by-marker approach, the role of different estrogen-related genes has been analyzed in different populations, but most of these studies ignore the complex multigenic nature of human osteoporosis. Looking for markers related to osteoporosis, we have analyzed five single nucleotide polymorphisms located in genes related to the estrogen pathway, Follicle Stimulating Hormone Receptor (FSHR) gene, the CYP19 aromatase (CYP19A1) gene, the Estrogen Receptor alpha (ESR1) gene, the Estrogen Receptor beta (ESR2) gene and the Nuclear Receptor Interacting Protein 1 (NRIP1) gene in 265 unrelated postmenopausal women. We have obtained nominal P values for the NRIP1 Gly75Gly and ESR2 *39A>G markers (P=0.013 and P=0.02 respectively), but no gene seems to be associated after multiple test corrections. Reanalysis of this study using 437 postmenopausal women confirmed our results and only detect marginal effects for ESR2 marker (P=0.045). By contrast, multilocus analysis predicted epistatic interactions between ESR1, ESR2 and NRIP1 loci and its involvement in postmenopausal osteoporosis (P=0.003). We detected two digenic genotypes involvin...Continue Reading
References
Jun 1, 1989·Calcified Tissue International·A DiezJ Vivancos
Jan 1, 1993·Bone·R Perez CanoG Dilsen
Mar 20, 1998·The Journal of Clinical Endocrinology and Metabolism·L GennariM L Brandi
Jun 18, 1999·The Journal of Clinical Endocrinology and Metabolism·P D MillerJ P Bilezikian
Mar 27, 2001·Molecular Endocrinology·J ZilliacusJ A Gustafsson
Aug 2, 2001·Human Genetics·J T den Dunnen, S E Antonarakis
Dec 4, 2001·Genome Research·J HohJ Ott
Aug 24, 2002·Endocrinology·Masae NaruseHiromi Hagiwara
Mar 29, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Sep 3, 2003·Nature Reviews. Genetics·Josephine Hoh, Jurg Ott
Nov 19, 2003·The Journal of Steroid Biochemistry and Molecular Biology·E R Simpson
Apr 30, 2004·Pharmacogenetics·Francisco de CastroAgustín Ruiz
May 11, 2004·European Journal of Endocrinology·Maria T ZarrabeitiaJosé A Riancho
May 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Göran LeonardssonMalcolm G Parker
Jun 3, 2004·Current Opinion in Genetics & Development·Josephine Hoh, Jurg Ott
Jun 19, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Gordon L KleinDavid N Herndon
Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·Ting-Chih ChengChen-Yang Shen
Nov 4, 2004·JAMA : the Journal of the American Medical Association·John P A IoannidisUNKNOWN GENOMOS Study
Oct 11, 2005·Fertility and Sterility·Jose J GalanAgustin Ruiz
Citations
May 29, 2010·Calcified Tissue International·T HarsløfB L Langdahl
Jan 27, 2010·Human Genetics·Wen-Feng LiJian-Min Chen
May 20, 2008·Annals of Human Genetics·D Karasik, S L Ferrari
Apr 11, 2012·BMC Medical Genetics·Johanna KorvalaMinna Männikkö
Apr 24, 2009·Reproductive Biology and Endocrinology : RB&E·Francesco MassartMaria Luisa Brandi
Mar 30, 2007·Pharmacogenomics·José A Riancho
Jul 20, 2007·Pharmacogenomics·Francisco Jesús MorónAgustín Ruiz
Feb 18, 2012·Climacteric : the Journal of the International Menopause Society·N MendozaT Martínez Astorquiza
Jul 14, 2012·European Journal of Medical Genetics·Johanna KorvalaMinna Männikkö
Feb 14, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·David Karasik, Douglas P Kiel
Nov 26, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Serge Ferrari
Nov 24, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nicolás MendozaRafael Sánchez Borrego
Dec 5, 2014·Molecular BioSystems·Xiaoyan LiuHongbin Xiao
Dec 3, 2016·Bone & Joint Research·J J LiD Li
Apr 14, 2017·JCI Insight·Bomi LeeLi-Na Wei
Apr 19, 2008·Reproductive Sciences·Nicolás MendozaAgustín Ruiz
Nov 8, 2006·Nuclear Receptor Signaling·Patrick AugereauVincent Cavaillès
Feb 21, 2018·BMC Endocrine Disorders·Heping ZhuLeiyan Zhang
Mar 1, 2008·Expert Review of Endocrinology & Metabolism·Yan GuoHong-Wen Deng
Jan 6, 2021·Genome Biology·Diana L CousminerStruan F A Grant
Jul 10, 2021·Oxidative Medicine and Cellular Longevity·Lang YangJunxiang Peng
Oct 31, 2020·Computers in Biology and Medicine·Zhi-Wen LiuXiao-Ling Shen