Multilocus sequence typing analysis reveals that Cryptococcus neoformans var. neoformans is a recombinant population

Fungal Genetics and Biology : FG & B
Massimo CogliatiAshok Varma

Abstract

Cryptococcus neoformans var. neoformans (serotype D) represents about 30% of the clinical isolates in Europe and is present less frequently in the other continents. It is the prevalent etiological agent in primary cutaneous cryptococcosis as well as in cryptococcal skin lesions of disseminated cryptococcosis. Very little is known about the genotypic diversity of this Cryptococcus subtype. The aim of this study was to investigate the genotypic diversity among a set of clinical and environmental C. neoformans var. neoformans isolates and to evaluate the relationship between genotypes, geographical origin and clinical manifestations. A total of 83 globally collected C. neoformans var. neoformans isolates from Italy, Germany, France, Belgium, Denmark, Greece, Turkey, Thailand, Japan, Colombia, and the USA, recovered from different sources (primary and secondary cutaneous cryptococcosis, disseminated cryptococcosis, the environment, and animals), were included in the study. All isolates were confirmed to belong to genotype VNIV by molecular typing and they were further investigated by MLST analysis. Maximum likelihood phylogenetic as well as network analysis strongly suggested the existence of a recombinant rather than a clonal popu...Continue Reading

References

Nov 7, 2000·Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology·R Ikeda, T Shinoda
Jan 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ségolène NeuvilleUNKNOWN French Cryptococcosis Study Group
Feb 27, 2003·Emerging Infectious Diseases·Wieland MeyerUNKNOWN IberoAmerican Cryptococcal Study Group
Dec 21, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M C EspostoM A Viviani
Feb 8, 2005·Journal of Clinical Microbiology·Anastasia P LitvintsevaThomas G Mitchell
May 16, 2006·FEMS Yeast Research·Kyung J Kwon-Chung, Ashok Varma
May 16, 2006·FEMS Yeast Research·Maria Anna VivianiUNKNOWN European Confederation of Medical Mycology (ECMM) Cryptococcosis Working Group
Jul 28, 2006·Molecular Biology and Evolution·Laura A KavanaughFred S Dietrich
Jan 19, 2011·Revista iberoamericana de micología·Jorge Alberto CortésUNKNOWN GREBO Group
Jan 5, 2013·Medical Mycology·Massimo CogliatiUNKNOWN Fimua Cryptococcosis Network
Feb 23, 2013·Japanese Journal of Infectious Diseases·Takashi UmeyamaYoshitsugu Miyazaki
May 20, 2014·Medical Microbiology and Immunology·Andrea SanchiniVolker Rickerts
Jul 6, 2014·Cold Spring Harbor Perspectives in Medicine·Kyung J Kwon-ChungYong-Sun Bahn
Oct 4, 2014·Clinical Microbiology Reviews·Sharon C-A ChenTania C Sorrell
Feb 28, 2015·Fungal Genetics and Biology : FG & B·Ferry HagenTeun Boekhout
Apr 18, 2015·Journal of Neurosciences in Rural Practice·Komi AssogbaEric K Grunitzky
May 23, 2015·Infection and Drug Resistance·Ana Espinel-Ingroff, Sarah E Kidd
Jun 11, 2015·MBio·Marie Desnos-OllivierUNKNOWN French Cryptococcosis Study Group
Jun 23, 2015·Current Opinion in Infectious Diseases·Andrés F Henao-Martínez, John David Beckham

❮ Previous
Next ❯

Citations

Mar 2, 2018·Journal of Fungi·Patricia EscandónElizabeth Castañeda
Apr 12, 2018·Memórias do Instituto Oswaldo Cruz·Carolina FiracativeUNKNOWN Latin American Cryptococcal Study Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.