Multilocus sequence typing: genetic diversity in Trypanosoma cruzi I (TcI) isolates from Brazilian didelphids

Parasites & Vectors
Fabiola RomanA M Jansen

Abstract

Trypanosoma cruzi is a protozoan parasite characterized by extensive genetic heterogeneity. There are currently six recognised, genetically distinct, monophyletic clades designated discrete typing units (DTUs). TcI has the broadest geographical range and most genetic diversity evidenced by a wide range of genetic markers applied to isolates spanning a vast geographical range across Latin America. However, little is known of the diversity of TcI that exists within sylvatic mammals across the geographical expanse of Brazil. Twenty-nine sylvatic TcI isolates spanning multiple ecologically diverse biomes across Brazil were analyzed by the application of multilocus sequence typing (MLST) using four nuclear housekeeping genes. Results revealed extensive genetic diversity and also incongruence among individual gene trees. There was no association of intralineage genotype with geography or with any particular biome, with the exception of isolates from Caatinga that formed a single cluster. However, haplotypic analyses of METIII and LYT1 constitutive markers provided evidence of recombination events in two isolates derived from Didelphis marsupialis and D. albiventris, respectively. For diversity studies all possible combinations of mar...Continue Reading

References

Nov 1, 1995·AIDS Research and Human Retroviruses·M O SalminenF E McCutchan
Dec 20, 1996·Molecular and Biochemical Parasitology·R P SoutoB Zingales
Jun 10, 2000·Memórias do Instituto Oswaldo Cruz·A M JansenO Fernandes
Sep 12, 2000·Bioinformatics·D Martin, E Rybicki
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·D Posada, K A Crandall
May 10, 2002·Trends in Parasitology·José Rodrigues CouraMichael A Miles
Feb 28, 2003·Nature·Michael W GauntMichael A Miles
Apr 3, 2003·International Journal for Parasitology·Nancy R SturmDavid A Campbell
Mar 31, 2004·Fungal Genetics and Biology : FG & B·Arianna TavantiDuncan J Shaw
Sep 21, 2004·Bioinformatics·D P MartinD Posada
Jul 7, 2005·Genetics·Scott J WestenbergerNancy R Sturm
Apr 13, 2006·PLoS Pathogens·Jorge M de FreitasSérgio D J Pena
Feb 9, 2007·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Claudia HerreraFelipe Guhl
Jun 8, 2007·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Olivia O'ConnorSimone Frédérique Brenière
Sep 25, 2007·Memórias do Instituto Oswaldo Cruz·Hugo Marcelo AguilarJosé Rodrigues Coura
Jan 1, 2008·Parasitology Research·Adeilton BrandaoOctavio E Sousa
Aug 15, 2008·Parasitology·M RozasJ-C Dujardin
Sep 17, 2008·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Angel E Spotorno OAldo Solari I
Oct 28, 2008·Experimental Parasitology·Ana María Mejía-JaramilloOmar Triana-Chávez
Apr 1, 2009·Emerging Infectious Diseases·Aglaêr A NóbregaWildo N Araujo
Sep 24, 2009·Memórias do Instituto Oswaldo Cruz·François Noireau
Dec 23, 2009·Memórias do Instituto Oswaldo Cruz·B ZingalesUNKNOWN Second Satellite Meeting
Mar 24, 2010·The Journal of Infectious Diseases·Belkisyolé Alarcón de NoyaOscar Noya
Nov 30, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Nicolás TomasiniPatricio Diosque
Jan 15, 2011·International Journal for Parasitology·Martin S LlewellynMichael A Miles
Jan 3, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Juan J LauthierPatricio Diosque
Jul 11, 2012·Molecular Ecology·Juan David RamírezMartin S Llewellyn
Jul 25, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Juan David RamírezFelipe Guhl
Sep 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Michel Tibayrenc, Francisco J Ayala
Apr 23, 2013·Trends in Parasitology·Michel Tibayrenc, Francisco J Ayala
Sep 13, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Nicolás TomasiniPatricio Diosque

❮ Previous
Next ❯

Citations

Mar 3, 2020·Frontiers in Cellular and Infection Microbiology·Ana Maria JansenAndré Luiz R Roque
Jan 15, 2020·Parasites & Vectors·Suheir EreqatZiad Abdeen
Oct 21, 2020·Parasitology Research·Wesley Arruda Gimenes NantesAna Maria Jansen
Mar 9, 2019·International Journal for Parasitology. Parasites and Wildlife·Marina Silva RodriguesAna Maria Jansen
Apr 13, 2019·International Journal for Parasitology. Parasites and Wildlife·Wesley Arruda Gimenes NantesHeitor Miraglia Herrera
Oct 4, 2019·Acta Tropica·Juan Jose LauthierMasataka Korenaga

❮ Previous
Next ❯

Datasets Mentioned

BETA
MG228353
MG868975
CP015651.1

Methods Mentioned

BETA
electrophoresis
PCRs
PCR

Software Mentioned

DNASTAR Lasergene SeqMan
TOPALi
MLSTest
GENECONV
PHASE
RDP3
Bio Edit
METIII
MLST
MrBayes

Related Concepts