Multimethod approach for the detection and characterisation of food-grade synthetic amorphous silica nanoparticles

Journal of Chromatography. a
Francisco BarahonaJosefa Barrero-Moreno

Abstract

Synthetic amorphous silica (SAS) has been used as food additive under the code E551 for decades and the agrifood sector is considered a main exposure vector for humans and environment. However, there is still a lack of detailed methodologies for the determination of SAS' particle size and concentration. This work presents the detection and characterization of NPs in eleven different food-grade SAS samples, following a reasoned and detailed sequential methodology. Dynamic Light Scattering (DLS), Multiangle Light Scattering (MALS), Asymmetric Flow-Field Flow Fractionation (AF4), Inductively Coupled Plasma Mass Spectrometry (ICPMS) and Transmission Electron Microscopy (TEM) were used. The suitability and limitations, information derived from each type of analytical technique and implications related to current EC Regulation 1169/2011 on the provision of food information to consumers are deeply discussed. In general the z-average, AF4 hydrodynamic diameters and root mean square (rms) radii measured were in good agreement. AF4-ICPMS coupling and pre channel calibration with silica NPs standards allowed the reliable detection of NPs below 100nm for ten of eleven samples (AF4 diameters between 20.6 and 39.8nm) and to quantify the mass...Continue Reading

References

Jul 31, 2007·Environmental Pollution·Bernd Nowack, Thomas D Bucheli
Nov 8, 2008·Particle and Fibre Toxicology·Peter BihariFritz Krombach
Sep 28, 2010·Nanotoxicology·Susan DekkersAgnes G Oomen
Mar 19, 2014·Chemosphere·Ahmed Al-KattanBernd Nowack
Jan 28, 2015·Food Chemistry·Agnieszka DudkiewiczThomas P J Linsinger
Jul 15, 2015·Regulatory Toxicology and Pharmacology : RTP·Valeria AmentaRuud J Peters

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Citations

Oct 5, 2016·Archives of Toxicology·Claudia Fruijtier-Pölloth
Jan 25, 2017·Analytical and Bioanalytical Chemistry·Catia Contado
Jan 17, 2018·EFSA Journal·UNKNOWN EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)Claude Lambré
Dec 26, 2018·Nanomaterials·Jean-Marie TeulonJean-Luc Pellequer
Jun 23, 2019·Analytical and Bioanalytical Chemistry·Otmar GeissJosefa Barrero

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